Evidence map›Paper›PMID 38459180›Full record

ArticleNature medicine2024

Sex-specific genetic architecture of blood pressure.

Min-Lee Yang, Chang Xu, Trisha Gupte, Thomas J Hoffmann, Carlos Iribarren, Xiang Zhou, Santhi K Ganesh

Open access · greenAbstract read
In one paragraph

Article in Nature medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
13.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 40 citations in OpenAlex.

  1. Review
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  8. Review
  9. Genetic factors contributing to atherosclerosis.Current opinion in cardiology · 2026
    Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Sex differences in LDL-C genetic architecture and statin efficacy in All of Us.medRxiv : the preprint server for health sciences · 2026
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Min-Lee YangDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA.
Chang XuDepartment of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Trisha GupteDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA.
Thomas J HoffmannDepartment of Epidemiology & Biostatistics, and Institute for Human Genetics, School of Medicine, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0001-6893-4449
Carlos IribarrenDivision of Research, Kaiser Permanente, Oakland, CA, USA.
Xiang ZhouDepartment of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Santhi K GaneshDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA. sganesh@umich.edu.ORCID 0000-0002-3663-5249
University of Michigan · USKaiser Permanente · USMichigan Medicine · USUniversity of California, San Francisco · US

Funding

Genome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2M
Genomic and Functional Studies of Dysplasia-Associated Arterial DiseasesR35HL161016 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SANTHI K GANESH · 2022 to 2026
$4.6M
Genetic Studies of The Impact of Hematologic Traits On Cardiovascular DiseaseR01HL122684 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GANESH, SANTHI K · 2015 to 2019
$3.4M
SHORT-TERM TRAINING IN HEALTH PROF SCHOOLST35HL007690 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FLAHERTY, KEVIN R · 1990 to 2024
$3.3M
Statistical Methods for Modeling Polygenic Architecture in Association and Re-sequencing StudiesR01HG009124 · NHGRI · YALE UNIVERSITY · PI Xiang Zhou · 2017 to 2026
$3.0M
Genetic and Genomic Analysis of Arterial DysplasiaR01HL139672 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GANESH, SANTHI K · 2018 to 2021
$2.9M
NHGRI NIH HHS R01 HG009124NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL122684NHLBI NIH HHS R01 HL139672NHLBI NIH HHS R35 HL161016NHLBI NIH HHS T35 HL007690U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R35HL161016U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (NHGRI) R01HG009124
6 · The paper itself

Abstract

The genetic and genomic basis of sex differences in blood pressure (BP) traits remain unstudied at scale. Here, we conducted sex-stratified and combined-sex genome-wide association studies of BP traits using the UK Biobank resource, identifying 1,346 previously reported and 29 new BP trait-associated loci. Among associated loci, 412 were female-specific (P

Indexed as

Cardiovascular DiseasesGenome-Wide Association StudyBlood PressureFemaleGenetic Predisposition to DiseaseGenomeHumansMaleMicrotubule-Associated ProteinsPhenotypePolymorphism, Single NucleotideMAP9 protein, humanMicrotubule-Associated Proteins

Identifiers

PMID38459180
PMCPMC11797078
OpenAlexW4392597465

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.