ArticleScientific reports2024
Mixture effects of trace element levels on cardiovascular diseases and type 2 diabetes risk in adults using G-computation analysis.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 14 citations in OpenAlex.
- The Effect of Serum Trace Element Levels On Cardiovascular Diseases in Adults in the Ravansar Region (Western Iran): A Risk Assessment Study in the Context of Elevated Lipid Profiles.Cardiovascular toxicology · 2026Article
- Association of serum essential and non-essential elements with dyslipidemia in patients with cardiovascular disease in Western Iran: an application of Bayesian kernel machine regression.BMC cardiovascular disorders · 2026Article
- Association Between Trace Elements and Sleep Duration in Patients with Type 2 Diabetes Mellitus: Evidence from a Kurdish Population in Western Iran.Biological trace element research · 2026Article
- Cross-sectional associations between plasma copper, zinc and prediabetes among rural Indian adolescent girls: baseline data from the DERVAN cohort (DERVAN-8).Journal of biosciences · 2026Article
- Metal Mixture Inflammatory Index and diabetes risk in US adults: a cross-sectional analysis of NHANES 1999-2020 and development of a LASSO-based prediction model.BMJ open diabetes research & care · 2025Article
- Serum levels of trace elements in diabetic pregnant women and their relationship with growth indicators in newborns.Scientific reports · 2025Article
- Regional concentrations of heavy metals in surface soils and risk of body pain in elderly residential population: a national cohort study in China.BMC public health · 2025Article
- Concentrations of trace metals in serum: Implications for type 2 diabetes mellitus and gender difference.Environmental analysis, health and toxicology · 2025Article
- Association between heavy metals and risk of cardiovascular diseases in US adults with prediabetes from NHANES 2011-2018.BMC public health · 2025Article
- Role of toxic and essential elements in sleep duration of patients with cardiovascular diseases.Scientific reports · 2025Article
- Association between blood essential metal elements in early pregnancy and gestational diabetes mellitus.Frontiers in nutrition · 2025Article
- The Evaluation of Selected Trace Elements in Blood, Serum and Blood Cells of Type 2 Diabetes Patients with and without Renal Disorder.Nutrients · 2024Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is an increasing concern about the health effects of exposure to a mixture of pollutants. This study aimed to evaluate the associations between serum levels of heavy/essential metals ([Arsenic (As), Cadmium (Cd), Mercury (Hg), Lead (Pb), Nickel (Ni), Chromium (Cr), Copper (Cu), Iron (Fe), and Zinc (Zn)]) and the risk of developing cardiovascular diseases (CVDs) and type 2 diabetes mellitus (T2D). Data were collected from 450 participants (150 with CVDs, 150 with T2D, and 150 healthy subjects) randomly selected from the Ravansar Non-Communicable Disease (RaNCD) cohort in Western Iran, covering the years 2018-2023. Trace element levels in the serum samples were assayed using ICP-MS. Logistic regression was performed to estimate the adjusted risk of exposure to single and multi-metals and CVD/T2D. Odds ratios were adjusted for age, sex, education, residential areas, hypertension, and BMI. The mixture effect of exposure to multi-metals and CVD/T2D was obtained using Quantile G-computation (QGC). In the logistic regression model, chromium, nickel, and zinc levels were associated with CVD, and significant trends were observed for these chemical quartiles (P < 0.001). Arsenic, chromium, and copper levels were also associated with T2D. The weight quartile sum (WQS) index was significantly associated with both CVD (OR 4.17, 95% CI 2.16-7.69) and T2D (OR 11.96, 95% CI 5.65-18.26). Cd, Pb, and Ni were the most heavily weighed chemicals in these models.The Cd had the highest weight among the metals in the CVD model (weighted at 0.78), followed by Hg weighted at 0.197. For T2D, the serum Pb (weighted at 0.32), Ni (weighted at 0.19), Cr (weighted at 0.17), and Cd (weighted at 0.14) were the most weighted in the G-computation model. The results showed the significant role of toxic and essential elements in CVDs and T2D risk. This association may be driven primarily by cadmium and mercury for CVDs and Pb, Ni, Cr, and Cd for T2D, respectively. Prospective studies with higher sample sizes are necessary to confirm or refute our preliminary results as well as to determine other important elements.
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