ArticleNature communications2024
Viscosity-dependent control of protein synthesis and degradation.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
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- Modulating the sialic acid content of endothelial cells affects their adhesion and barrier permeability.Scientific reports · 2026Article
- Mechanosensing at the endoplasmic reticulum by IRE1.Research square · 2026Article
- Review
- Histone lactylation maintains bovine early embryo development via regulating embryonic genome activation.Journal of animal science and biotechnology · 2026Article
- The biophysical properties of the bacterial nucleoid are dynamic, heterogeneous, and responsive to perturbations of cellular processes.bioRxiv : the preprint server for biology · 2026Article
- Cytoplasmic crowding acts as a porous medium reducing macromolecule diffusion.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- How does cytoplasmic crowding affect reaction rates?Molecular cell · 2026Review
- Cells prioritize the regulation of cell mass density.Science advances · 2025Article
- Single-particle tracking of genetically encoded nanoparticles: Optimizing expression for cytoplasmic diffusion studies.Biophysical journal · 2025Article
- Cytoplasmic control of spindle architecture.Nature cell biology · 2025Article
- Molecular and Biophysical Perspectives on Dormancy Breaking: Lessons from Yeast Spore.Biomolecules · 2025Review
- Somatic polyploidy supports biosynthesis and tissue function by increasing transcriptional output.The Journal of cell biology · 2025Article
- Measuring Molecular Mass Densities at Subcellular Resolution Using Optical Diffraction Tomography.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Single-molecule diffusivity quantification inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Robust trigger wave speed in Xenopus cytoplasmic extracts.Nature communications · 2024Article
- Cytoplasmic fluidization contributes to breaking spore dormancy in fission yeast.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
It has been proposed that the concentration of proteins in the cytoplasm maximizes the speed of important biochemical reactions. Here we have used Xenopus egg extracts, which can be diluted or concentrated to yield a range of cytoplasmic protein concentrations, to test the effect of cytoplasmic concentration on mRNA translation and protein degradation. We find that protein synthesis rates are maximal in ~1x cytoplasm, whereas protein degradation continues to rise to a higher optimal concentration of ~1.8x. We show that this difference in optima can be attributed to a greater sensitivity of translation to cytoplasmic viscosity. The different concentration optima could produce a negative feedback homeostatic system, where increasing the cytoplasmic protein concentration above the 1x physiological level increases the viscosity of the cytoplasm, which selectively inhibits translation and drives the system back toward the 1x set point.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.