ArticleNature communications2024
A persistent prefrontal reference frame across time and task rules.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Neural Mechanisms of Neuroticism: Large-Scale Brain Networks, Developmental Trajectories, and Translational Implications.Brain sciences · 2026Review
- Anterior cingulate neurons combine outcome monitoring of past decisions with ongoing movement signals.Nature communications · 2026Article
- Article
- Environmental enrichment accelerates the stabilization of cortical representation duringiScience · 2026Article
- Fragmentation and multithreading of experience in the default-mode network.Nature communications · 2025Article
- Graded remapping of prefrontal representations preserves a cumulative record of distinct events within an environment.iScience · 2025Article
- Environmental enrichment accelerates cortical memory consolidation.bioRxiv : the preprint server for biology · 2025Article
- Perceptual and semantic maps in individual humans share structural features that predict creative abilities.Communications psychology · 2025Article
- The representation of decision variables in orbitofrontal cortex is longitudinally stable.Cell reports · 2024Article
- Neuronal tuning to threat exposure remains stable in the mouse prefrontal cortex over multiple days.PLoS biology · 2024Article
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Authors and funding
7 authors.
Funding
Abstract
Behavior can be remarkably consistent, even over extended time periods, yet whether this is reflected in stable or 'drifting' neuronal responses to task features remains controversial. Here, we find a persistently active ensemble of neurons in the medial prefrontal cortex (mPFC) of mice that reliably maintains trajectory-specific tuning over several weeks while performing an olfaction-guided spatial memory task. This task-specific reference frame is stabilized during learning, upon which repeatedly active neurons show little representational drift and maintain their trajectory-specific tuning across long pauses in task exposure and across repeated changes in cue-target location pairings. These data thus suggest a 'core ensemble' of prefrontal neurons forming a reference frame of task-relevant space for the performance of consistent behavior over extended periods of time.
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Registered trials
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