Evidence map›Paper›PMID 38458648›Full record

ArticleLife science alliance2024

C5aR plus MEK inhibition durably targets the tumor milieu and reveals tumor cell phagocytosis.

Melissa R Perrino, Niousha Ahmari, Ashley Hall, Mark Jackson, Youjin Na, Jay Pundavela, Sara Szabo, Trent M Woodruff, Eva Dombi, Mi-Ok Kim and 3 more

Open access · goldAbstract read
In one paragraph

Article in Life science alliance, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Melissa R PerrinoDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0000-0002-0598-7102
Niousha AhmariDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Ashley HallDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Mark JacksonDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Youjin NaDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Jay PundavelaDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0000-0003-2861-4736
Sara SzaboDepartmentd of Pediatrics and Pediatric Pathology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA.ORCID 0000-0002-6212-7264
Trent M WoodruffSchool of Biomedical Sciences, The University of Queensland, St Lucia, Australia.
Eva DombiPediatric Oncology Branch, National Cancer Institute, Bethesda, MD, USA.ORCID 0000-0002-5323-6995
Mi-Ok KimDepartment Biostatistics, University of California, San Francisco, CA, USA.
Jörg KöhlDepartment of Pediatrics, University of Cincinnati, Cincinnati, OH, USA.ORCID 0000-0003-1121-3178
Jianqiang WuDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA Jianqiang.Wu@cchmc.org.ORCID 0000-0002-4239-5659
Nancy RatnerDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA Nancy.ratner@cchmc.org.ORCID 0000-0001-5030-9354
Cincinnati Children's Hospital Medical Center · USNational Cancer Institute · USThe University of Queensland · AUUniversity of California, San Francisco · US

Funding

Targeting Complement 5a-Mediated Immunoregulation for Neurofibroma TherapyR33NS112407 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI RATNER, NANCY, WU, JIANQIANG · 2021 to 2022
$789k
Targeting complement 5a-mediated immunoregulation for neurofibroma therapyR61NS112407 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI RATNER, NANCY, WU, JIANQIANG · 2019 to 2019
$398k
NINDS NIH HHS R33 NS112407NINDS NIH HHS R61 NS112407
6 · The paper itself

Abstract

Plexiform neurofibromas (PNFs) are nerve tumors caused by loss of

Indexed as

CytophagocytosisNeurofibroma, PlexiformHumansMacrophagesMitogen-Activated Protein Kinase KinasesReceptor, Anaphylatoxin C5aSignal TransductionTumor MicroenvironmentC5AR1 protein, humanMitogen-Activated Protein Kinase KinasesReceptor, Anaphylatoxin C5a

Identifiers

PMID38458648
PMCPMC10923703
OpenAlexW4392601211

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.