Evidence map›Paper›PMID 38458192›Full record

ArticleCurrent biology : CB2024

Dissociable encoding of motivated behavior by parallel thalamo-striatal projections.

Sofia Beas, Isbah Khan, Claire Gao, Gabriel Loewinger, Emma Macdonald, Alison Bashford, Shakira Rodriguez-Gonzalez, Francisco Pereira, Mario A Penzo

Abstract read
In one paragraph

Article in Current biology : CB, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Sofia BeasUnit on the Neurobiology of Affective Memory, National Institute of Mental Health, Convent Drive, Bethesda, MD 20892, USA; Department of Neurobiology, University of Alabama at Birmingham, University Boulevard, Birmingham, AL 35294, USA. Electronic address: sbeas@uab.edu.
Isbah KhanUnit on the Neurobiology of Affective Memory, National Institute of Mental Health, Convent Drive, Bethesda, MD 20892, USA.
Claire GaoUnit on the Neurobiology of Affective Memory, National Institute of Mental Health, Convent Drive, Bethesda, MD 20892, USA.
Gabriel LoewingerMachine Learning Team, National Institute of Mental Health, Convent Drive, Bethesda, MD 20892, USA.
Emma MacdonaldUnit on the Neurobiology of Affective Memory, National Institute of Mental Health, Convent Drive, Bethesda, MD 20892, USA.
Alison BashfordUnit on the Neurobiology of Affective Memory, National Institute of Mental Health, Convent Drive, Bethesda, MD 20892, USA.
Shakira Rodriguez-GonzalezUnit on the Neurobiology of Affective Memory, National Institute of Mental Health, Convent Drive, Bethesda, MD 20892, USA.
Francisco PereiraMachine Learning Team, National Institute of Mental Health, Convent Drive, Bethesda, MD 20892, USA.
Mario A PenzoUnit on the Neurobiology of Affective Memory, National Institute of Mental Health, Convent Drive, Bethesda, MD 20892, USA. Electronic address: mario.penzo@nih.gov.

Funding

Dissecting the stress circuits of the paraventricular nucleus of the thalamusZIAMH002950 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PENZO, MARIO · 2016 to 2025
$17.5M
Machine Learning TeamZICMH002968 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PEREIRA, FRANCISCO · 2018 to 2025
$13.9M
Mapping Thalamo-striatal Neuronal Circuits Underlying Motivational DriveR00MH126429 · NIMH · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BEAS, SOFIA · 2022 to 2024
$796k
NIMH NIH HHS R00 MH126429
6 · The paper itself

Abstract

The successful pursuit of goals requires the coordinated execution and termination of actions that lead to positive outcomes. This process relies on motivational states that are guided by internal drivers, such as hunger or fear. However, the mechanisms by which the brain tracks motivational states to shape instrumental actions are not fully understood. The paraventricular nucleus of the thalamus (PVT) is a midline thalamic nucleus that shapes motivated behaviors via its projections to the nucleus accumbens (NAc)

Indexed as

MotivationNucleus AccumbensAnimalsHypothalamusMiceMidline Thalamic NucleiThalamusFLMM analysisfood-seekinggoal terminationmotivationnucleus accumbensparaventricular nucleus of the thalamusreward approach

Identifiers

PMID38458192
PMCPMC11003833

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.