Evidence map›Paper›PMID 38457761›Full record

Trial reportJournal of clinical oncology : official journal of the American Society of Clinical Oncology2024

Francesca Battaglin, Fang-Shu Ou, Xueping Qu, Howard S Hochster, Donna Niedzwiecki, Richard M Goldberg, Robert J Mayer, Karam Ashouri, Tyler J Zemla, Charles D Blanke and 4 more

Open access · greenAbstract readClinical Trial, Phase III
In one paragraph

Trial report in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 9 institutions in 1 country.

Francesca BattaglinUniversity of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA.ORCID 0000-0002-9869-0163
Fang-Shu OuAlliance Statistics and Data Management Center, Mayo Clinic, Rochester, MN.ORCID 0000-0003-1267-8735
Xueping QuGenentech, San Francisco, CA.
Howard S HochsterYale Cancer Center, New Haven, CT.ORCID 0000-0002-9893-1529
Donna NiedzwieckiDuke Cancer Institute, Duke University Medical Center, Durham, NC.ORCID 0000-0002-3566-0450
Richard M GoldbergWest Virginia University Cancer Institute, Morgantown, WV.ORCID 0000-0003-0308-8223
Robert J MayerDana-Farber/Partners CancerCare, Boston, MA.
Karam AshouriUniversity of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA.ORCID 0009-0000-1825-1033
Tyler J ZemlaAlliance Statistics and Data Management Center, Mayo Clinic, Rochester, MN.
Charles D BlankeOregon Health & Science University, Portland, OR.
Alan P VenookUniversity of California, San Francisco, San Francisco, CA.ORCID 0000-0001-9749-6548
Omar KabbarahGenentech, San Francisco, CA.
Heinz-Josef LenzUniversity of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA.ORCID 0000-0003-2178-9568
Federico InnocentiUniversity of North Carolina at Chapel Hill, Chapel Hill, NC.ORCID 0000-0001-9247-979X
University of Southern California · USMayo Clinic · USCancerCare · USDuke Medical Center · USOregon Health & Science University · USUniversity of California, San Francisco · USUniversity of North Carolina at Chapel Hill · USWest Virginia University · USYale Cancer Center · US

Funding

Member Site CoreU10CA180821 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI Evanthia Galanis · 2014 to 2026
$177.3M
Project-006U10CA180820 · NCI · ECOG-ACRIN MEDICAL RESEARCH FOUNDATION · PI Peter J ODwyer · 2014 to 2026
$167.6M
SWOG Network Group Operations Center of the NCTNU10CA180888 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI PRIMO N. LARA · 2014 to 2026
$152.1M
Statistics CoreU10CA180882 · NCI · MAYO CLINIC ROCHESTER · PI Sumithra Jay Mandrekar · 2014 to 2026
$115.0M
NCIC Clinical Trials Group - Canadian Collaborating Clinical Trials NetworkU10CA180863 · NCI · QUEEN'S UNIVERSITY AT KINGSTON · PI Janet Ellen Dancey · 2014 to 2026
$40.4M
NCTN Lead Academic Participating Site at Dana-Farber/Partners Cancer CareUG1CA233180 · NCI · DANA-FARBER CANCER INST · PI Harold John Burstein · 2019 to 2026
$8.6M
Yale Cancer Center NCTN LAPSUG1CA233337 · NCI · YALE UNIVERSITY · PI ANNE C CHIANG · 2019 to 2026
$6.0M
The Duke University - Duke Cancer Institute National Clinical Trials Network LAPS (UG1) Support GrantUG1CA233253 · NCI · DUKE UNIVERSITY · PI John H Strickler, Alexandra Thomas · 2019 to 2026
$3.7M
UNC Lead Academic Participating SiteUG1CA233373 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CAREY, LISA A, DEES, ELIZABETH CLAIRE · 2019 to 2025
$3.5M
NCTN - Network Lead Academic Participating Site: USCUG1CA180830 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Anthony Boutros El-Khoueiry, Amir Goldkorn · 2019 to 2026
$3.2M
NCI NIH HHS U10 CA180820NCI NIH HHS U10 CA180821NCI NIH HHS U10 CA180863NCI NIH HHS U10 CA180882NCI NIH HHS U10 CA180888NCI NIH HHS UG1 CA180830NCI NIH HHS UG1 CA233180NCI NIH HHS UG1 CA233253NCI NIH HHS UG1 CA233337NCI NIH HHS UG1 CA233373
6 · The paper itself

Abstract

purposeThe phase III Cancer and Leukemia Group B (CALGB)/SWOG 80405 trial found no difference in overall survival (OS) in patients with metastatic colorectal cancer receiving first-line chemotherapy in combination with either bevacizumab or cetuximab. We investigated the potential prognostic and predictive value of PATIENTS AND

methodsPrimary tumor DNA from 559 patients was profiled for

resultsHigh

conclusion

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsBevacizumabCetuximabColorectal NeoplasmsErb-b2 Receptor Tyrosine KinasesAdultAgedBiomarkers, TumorFemaleGene Expression Regulation, NeoplasticHumansMaleMiddle AgedNeoplasm MetastasisPrognosisProgression-Free SurvivalBevacizumabBiomarkers, TumorCetuximabERBB2 protein, humanErb-b2 Receptor Tyrosine Kinases

Identifiers

PMID38457761
PMCPMC11240881
OpenAlexW4392579900

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.