Evidence map›Paper›PMID 38457215›Full record

ArticleCancer medicine2024

Impact of measurable residual disease in combination with CD19 on postremission therapy choices for adult t(8;21) acute myeloid leukemia in first complete remission.

Xi Jia, Naying Liao, Sijian Yu, Huan Li, Hui Liu, Haiyan Zhang, Jun Xu, Yunqian Yao, Han He, Guopan Yu and 3 more

Open access · goldAbstract read
In one paragraph

Article in Cancer medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Xi JiaDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Naying LiaoDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Sijian YuDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Huan LiDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Hui LiuDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Haiyan ZhangDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Jun XuDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China.ORCID 0000-0001-7621-3617
Yunqian YaoDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Han HeDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Guopan YuDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Qifa LiuDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China.ORCID 0000-0003-4015-3952
Yu ZhangDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Pengcheng ShiDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China.ORCID 0000-0002-5626-3366
Nanfang Hospital · CN

Funding

National Natural Science Foundation of China 82370152Natural Science Foundation of Guangdong Province 2020A1515010406
6 · The paper itself

Abstract

backgroundThe post-remission therapy (PRT) choices for adult t(8;21) acute myeloid leukemia (AML) in first complete remission (CR1) need to be further explored.

aimsWe aimed to investigate the impact of measurable residual disease (MRD) combined with CD19 on PRT choices for adult t(8;21) AML in CR1.

methodsA total of 150 t(8;21) AML patients were enrolled, including 67 underwent chemotherapy (CMT) and 83 allogeneic hematopoietic stem cell transplantation (allo-SCT) as PRT in CR1. Subgroup analyses were performed according to MRD level after three cycles of chemotherapy combined with CD19 expression.

resultsMultivariate analysis indicated MRD

conclusionsMRD combined with CD19 might optimize PRT choices for adult t(8;21) AML patients in CR1.

Indexed as

Hematopoietic Stem Cell TransplantationLeukemia, Myeloid, AcuteAdultHumansNeoplasm, ResidualPathologic Complete ResponsePrognosisRecurrenceRetrospective StudiesStem Cell TransplantationTransplantation, Homologousallogeneic stem cell transplantationCD19chemotherapyMRDt(8;21) AML

Identifiers

PMID38457215
PMCPMC10922018
OpenAlexW4392605369

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.