Evidence map›Paper›PMID 38457113›Full record

ArticleInternational journal of hematology2024

Prevalence of chromosome 8p11.2 translocations and correlation with myeloid and lymphoid neoplasms associated with FGFR1 abnormalities in a consecutive cohort from nine institutions in Japan.

Kensuke Usuki, Takuro Kameda, Noriaki Kawano, Tomoki Ito, Yoshinori Hashimoto, Kotaro Shide, Hiroshi Kawano, Masaaki Sekine, Takanori Toyama, Hiromitsu Iizuka and 8 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of hematology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Kensuke UsukiDepartment of Hematology, NTT Medical Center Tokyo, Tokyo, Japan.
Takuro KamedaDivision of Hematology, Diabetes, and Endocrinology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Noriaki KawanoMiyazaki Prefectural Miyazaki Hospital, Miyazaki, Japan.
Tomoki ItoFirst Department of Internal Medicine, Kansai Medical University, Osaka, Japan.
Yoshinori HashimotoDepartment of Hematology, Tottori Prefectural Central Hospital, Tottori, Japan.
Kotaro ShideDivision of Hematology, Diabetes, and Endocrinology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Hiroshi KawanoKoga General Hospital, Miyazaki, Japan.
Masaaki SekineKoga General Hospital, Miyazaki, Japan.
Takanori ToyamaMiyazaki Prefectural Nobeoka Hospital, Nobeoka, Japan.
Hiromitsu IizukaDepartment of Hematology, NTT Medical Center Tokyo, Tokyo, Japan.
Seiichi SatoMiyakonojo Medical Center, Miyakonojo, Japan.
Masanori TakeuchiAisenkai Nichinan Hospital, Nichinan, Japan.
Junzo IshizakiAisenkai Nichinan Hospital, Nichinan, Japan.
Kouichi MaedaMiyakonojo Medical Center, Miyakonojo, Japan.
Michikazu NakaiClinical Research Support Center, University of Miyazaki Hospital, Miyazaki, Japan.
Kiyoshi YamashitaMiyazaki Prefectural Miyazaki Hospital, Miyazaki, Japan.
Yoko KubukiDivision of Hematology, Diabetes, and Endocrinology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Kazuya ShimodaDivision of Hematology, Diabetes, and Endocrinology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan. kshimoda@med.miyazaki-u.ac.jp.ORCID http://orcid.org/0000-0002-2555-8188

Funding

University of Miyazaki Hospital R5
6 · The paper itself

Abstract

Myeloid and lymphoid neoplasms associated with FGFR1 abnormalities (MLN-FGFR1 abnormalities) are rare hematologic malignancies associated with chromosome 8p11.2 abnormalities. Translocations of 8p11.2 were detected in 10 of 17,039 (0.06%) unique patient cytogenetic studies performed at nine institutions in Japan. No inversions or insertions of 8p11.2 were detected. Among the 10 patients with 8p11.2 translocations, three patients were diagnosed with MLN-FGFR1 abnormalities, which were confirmed by FISH analysis. Peripheral blood eosinophilia was observed in all three patients, and all progressed to AML or T-lymphoblastic lymphoma/leukemia. The prevalence of 8p11.2 translocations in clinical practice and the proportion of MLN-FGFR1 abnormalities in patients with 8p11.2 translocations in Japan were consistent with those in previous reports from Western countries.

Indexed as

Chromosomes, Human, Pair 8Receptor, Fibroblast Growth Factor, Type 1Translocation, GeneticAdultAgedCohort StudiesFemaleHumansIn Situ Hybridization, FluorescenceJapanLymphomaMaleMiddle AgedPrevalenceFGFR1 protein, humanReceptor, Fibroblast Growth Factor, Type 18p11EosinophiliaFGFR1

Identifiers

PMID38457113
PMCPMC11136786

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.