Observational studyQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2024
Health-related quality of life and associated risk factors in patients with Multiple Osteochondromas: a cross-sectional study.
Observational study in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 3 citations in OpenAlex.
- Clinical decision-making in rare bone diseases - A survey among members of the European Paediatric Orthopaedic Society (EPOS) and the European Reference Network on Rare Bone Diseases (ERN BOND).Journal of children's orthopaedics · 2026Article
- Fatigue and pain in children with multiple osteochondromas: a cross-sectional study.Orphanet journal of rare diseases · 2026Article
- Health-related quality of life and physical activity in children with Multiple Osteochondromas.Journal of bone oncology · 2026Article
- Pain in patients with multiple inherited osteochondromas: Incidence and potential prognostic factors. A retrospective cohort study.Journal of bone oncology · 2025Article
- A Novel Pathogenic Large Duplication in EXT1 Identified in a Family with Multiple Osteochondromas.Genes · 2024Article
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Authors and funding
15 authors at 1 institution in 1 country.
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Abstract
purposeTo evaluate the health-related quality of life and associated risk factors for Multiple Osteochondromas patients.
methodsA cross-sectional, observational study was conducted from May to December 2022 during the routine visit to the referral center for rare skeletal disorders. All patients with Multiple Osteochondromas aged ≥ 3 years were included. EuroQol 5-dimension questionnaires, and demographic, clinical, and surgical history data were collected. Descriptive statistics, Fisher's exact test, One-sample t-test, Spearman's correlation, and multiple linear and logistic regression were performed to analyze the data. Results are reported following STROBE guidelines.
resultsA total of 128 patients were included in the study, with a mean age of 14 [SD, 10] years. The mean EQ-5D Index Value was 0.863 [SD, 0.200] and the EQ-VAS was 84 [SD, 19] with a positive correlation between two scores [r = 0.541, p < 0.001]. Patients frequently referred problems in pain/discomfort [78.8%], anxiety/depression [50%], and usual activities [38.8%] dimensions. Increasing age was the common risk factor for health-related quality of life [p < 0.000], as well as Index Value and VAS scores were significantly lower in surgical patients [p = 0.001 and p < 0.001, respectively].
conclusionIncreasing age and surgical procedures were found highly associated with reduced health-related quality of life in Multiple Osteochondromas patients. Our findings provide relevant information to support the establishment of patient-centered healthcare pathways and pave the way for further research into medical and non-medical therapeutic strategies for these patients.
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