Evidence map›Paper›PMID 38456971›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2024

Artificial intelligence-based, volumetric assessment of the bone marrow metabolic activity in [

Christos Sachpekidis, Olof Enqvist, Johannes Ulén, Annette Kopp-Schneider, Leyun Pan, Elias K Mai, Marina Hajiyianni, Maximilian Merz, Marc S Raab, Anna Jauch and 3 more

Erratum issuedAbstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. The [European journal of nuclear medicine and molecular imaging · 2026
    Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Review
  6. Article
  7. Article
  8. Lesion conspicuity by size in [EJNMMI research · 2026
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Christos SachpekidisClinical Cooperation Unit Nuclear Medicine, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69210, Heidelberg, Germany. c.sachpekidis@dkfz-heidelberg.de.ORCID 0000-0001-8739-8741
Olof EnqvistEigenvision AB, Malmö, Sweden.
Johannes UlénEigenvision AB, Malmö, Sweden.
Annette Kopp-SchneiderDivision of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Leyun PanClinical Cooperation Unit Nuclear Medicine, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69210, Heidelberg, Germany.
Elias K MaiDepartment of Internal Medicine V, University Hospital Heidelberg and National Center for Tumor Diseases (NCT), Heidelberg, Germany.
Marina HajiyianniDepartment of Internal Medicine V, University Hospital Heidelberg and National Center for Tumor Diseases (NCT), Heidelberg, Germany.
Maximilian MerzDepartment of Hematology and Cell Therapy, University of Leipzig, Leipzig, Germany.
Marc S RaabDepartment of Internal Medicine V, University Hospital Heidelberg and National Center for Tumor Diseases (NCT), Heidelberg, Germany.
Anna JauchInstitute of Human Genetics, University of Heidelberg, Heidelberg, Germany.
Hartmut GoldschmidtDepartment of Internal Medicine V, University Hospital Heidelberg and National Center for Tumor Diseases (NCT), Heidelberg, Germany.
Lars EdenbrandtDepartment of Clinical Physiology, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden.
Antonia Dimitrakopoulou-StraussClinical Cooperation Unit Nuclear Medicine, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69210, Heidelberg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeMultiple myeloma (MM) is a highly heterogeneous disease with wide variations in patient outcome. [ MATERIALS AND

methodsForty-four, previously untreated MM patients underwent whole-body [

resultsMedian follow-up [95% CI] of the patient cohort was 110 months [105-123 months]. AI-based BM segmentation and calculation of MTV and TLG were feasible in all patients. A significant, positive, moderate correlation was observed between the automated quantitative whole-body PET/CT parameters, MTV and TLG, and BM plasma cell infiltration for all ten [

conclusionsThe AI-based, whole-body calculations of BM metabolism via the parameters MTV and TLG not only correlate with the degree of BM plasma cell infiltration, but also predict patient survival in MM. In particular, the parameter MTV, using the liver uptake as reference for BM segmentation, provides solid prognostic information for disease progression. In addition to highlighting the prognostic significance of automated, global volumetric estimation of metabolic tumor burden, these data open up new perspectives towards solving the complex problem of interpreting PET scans in MM with a simple, fast, and robust method that is not affected by operator-dependent interventions.

Indexed as

Artificial IntelligenceBone MarrowFluorodeoxyglucose F18Multiple MyelomaPositron Emission Tomography Computed TomographyAdultAgedAged, 80 and overFemaleHumansImage Processing, Computer-AssistedMaleMiddle AgedPrognosisSurvival AnalysisFluorodeoxyglucose F18[18F]FDG PET/CTArtificial intelligenceDeep learningMetabolic tumor volume (MTV)Multiple myelomaPatient survivalPrognosisTotal lesion glycolysis (TLG)

Identifiers

PMID38456971
PMCPMC11178614

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.