Evidence map›Paper›PMID 38456690›Full record

Observational studyJournal of clinical microbiology2024

Prospective observational pilot study of the T2Resistance panel in the T2Dx system for detection of resistance genes in bacterial bloodstream infections.

Thomas J Walsh, Antonella Mencacci, Riccardo Paggi, Evangelia Douka, Charikleia Vrettou, Roger Smith, Oscar Guzman

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of clinical microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Thomas J WalshCenter for Innovative Therapeutics and Diagnostics, Richmond, Virginia, USA.ORCID 0000-0002-7078-9778
Antonella MencacciMicrobiology and Clinical Microbiology, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
Riccardo PaggiMicrobiology and Clinical Microbiology, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
Evangelia DoukaFirst Department of Critical Care, University of Athens, Evangelismos General Hospital, Athens, Greece.
Charikleia VrettouFirst Department of Critical Care, University of Athens, Evangelismos General Hospital, Athens, Greece.
Roger SmithT2 Biosystems, Lexington, Massachusetts, USA.
Oscar GuzmanT2 Biosystems, Lexington, Massachusetts, USA.
National and Kapodistrian University of Athens · GRUniversity of Perugia · ITUniversity of Maryland, Baltimore · US

Funding

T2 Biosystems
6 · The paper itself

Abstract

Early initiation of antimicrobial therapy targeting resistant bacterial pathogens causing sepsis and bloodstream infections (BSIs) is critical for a successful outcome. The T2Resistance Panel (T2R) detects the following resistance genes within organisms that commonly cause BSIs directly from patient blood samples: IMPORTANCE: This is the first reported study to our knowledge to identify key bacterial resistance genes directly from the bloodstream within 3 to 5 hours in patients with bloodstream infections and sepsis. The study further demonstrated a direct effect in modifying initial empirical antibacterial therapy in response to T2R signal to treat resistant bacteria causing bloodstream infections and sepsis.

Indexed as

Anti-Infective AgentsBacteremiaBacterial InfectionsSepsisAnti-Bacterial AgentsBacteriaHumansMicrobial Sensitivity TestsPilot ProjectsProspective StudiesAnti-Bacterial AgentsAnti-Infective Agentsblood culturesrapid molecular diagnosisresistance genessepsisT2

Identifiers

PMID38456690
PMCPMC11005387
OpenAlexW4392586075

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.