Evidence map›Paper›PMID 38456645›Full record

ArticleThe Journal of international medical research2024

Effects of adipose-derived cell supplementation on tendon-bone healing in a rat model of chronic rotator cuff tear with suprascapular nerve injury.

Kenichiro Eshima, Hiroki Ohzono, Masafumi Gotoh, Ryunosuke Abe, Hidehiro Nakamura, Yasuhiro Mitsui, Koji Hiraoka, Takahiro Okawa

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of international medical research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Kenichiro EshimaDepartment of Orthopedic Surgery, Social insurance Tagawa Hospital, 10-18 kamihon-machi, Tagawa, Fukuoka 826-0023, Japan.
Hiroki OhzonoDepartment of Orthopedic Surgery, Kurume University Medical Center, 151-1 Kokubu-machi, Kurume, Fukuoka 839-0863, Japan.ORCID 0000-0001-7170-5401
Masafumi GotohDepartment of Orthopedic Surgery, Kurume University Medical Center, 151-1 Kokubu-machi, Kurume, Fukuoka 839-0863, Japan.
Ryunosuke AbeDepartment of Orthopedic Surgery, Kurume University Medical Center, 151-1 Kokubu-machi, Kurume, Fukuoka 839-0863, Japan.
Hidehiro NakamuraDepartment of Orthopedic Surgery, Kurume University Medical Center, 151-1 Kokubu-machi, Kurume, Fukuoka 839-0863, Japan.
Yasuhiro MitsuiDepartment of Orthopedic Surgery, Hyakutake Hospital, 4-2-15 mizugae, Saga city, Saga 840-0054, Japan.
Koji HiraokaDepartment of Orthopedic Surgery, Kurume University Hospital, 67 Asahi-machi, Kurume Fukuoka 830-0011, Japan.
Takahiro OkawaDepartment of Orthopedic Surgery, Kurume University Medical Center, 151-1 Kokubu-machi, Kurume, Fukuoka 839-0863, Japan.
Kurume University Medical Center · JPKurume University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the effect of adipose-derived cells (ADCs) on tendon-bone healing in a rat model of chronic rotator cuff tear (RCT) with suprascapular nerve (SN) injury.

methodsAdult rats underwent right shoulder surgery whereby the supraspinatus was detached, and SN injury was induced. ADCs were cultured from the animals' abdominal fat. At 6 weeks post-surgery, the animals underwent surgical tendon repair; the ADC (+ve) group (n = 18) received an ADC injection, and the ADC (-ve) group (n = 18) received a saline injection. Shoulders were harvested at 10, 14, and 18 weeks and underwent histological, fluorescent, and biomechanical analyses.

resultsIn the ADC (+ve) group, a firm enthesis, including dense mature fibrocartilage and well-aligned cells, were observed in the bone-tendon junction and fatty infiltration was less than in the ADC (-ve) group. Mean maximum stress and linear stiffness was greater in the ADC (+ve) compared with the ADC (-ve) group at 18 weeks.

conclusionADC supplementation showed a positive effect on tendon-bone healing in a rat model of chronic RCT with accompanying SN injury. Therefore, ADC injection may possibly accelerate recovery in massive RCT injuries.

Indexed as

Peripheral Nerve InjuriesRotator Cuff InjuriesAnimalsBiomechanical PhenomenaDietary SupplementsDisease Models, AnimalRatsTendonsWound Healingadipose-derived cellsanimal modelbone-tendon interface healingrotator cuff tearSuprascapular nerve injury

Identifiers

PMID38456645
PMCPMC10924565
OpenAlexW4392598818

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.