Evidence map›Paper›PMID 38456514›Full record

ReviewMultiple sclerosis (Houndmills, Basingstoke, England)2024

Expert opinion on the use of contraception in people with multiple sclerosis.

Jan Hillert, Riley Bove, Lisa B Haddad, Kerstin Hellwig, Maria Houtchens, Melinda Magyari, Gabriele S Merki-Feld, Scott Montgomery, Rossella E Nappi, Egon Stenager and 4 more

Open access · hybridAbstract readReview
In one paragraph

Review in Multiple sclerosis (Houndmills, Basingstoke, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Review
  3. Sex and gender-related differences in neurological diseases: current challenges and recommendations for clinical practice.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 14 institutions in 8 countries.

Jan HillertDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-7386-6732
Riley BoveUCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-2034-8800
Lisa B HaddadCenter for Biomedical Research, Population Council, New York, NY, USA.
Kerstin HellwigKatholisches Klinikum Bochum GmbH, Nordrhein-Westfalen, Bochum, Germany.ORCID 0000-0003-4467-9011
Maria HoutchensBrigham and Women's Hospital, Boston, MA, USA/ Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-6077-0654
Melinda MagyariDanish Multiple Sclerosis Center, University Hospital Boston, MA, USA/ Rigshospitalet, Copenhagen, Denmark.
Gabriele S Merki-FeldClinic of Reproductive Endocrinology, University Hospital Zürich, Zürich, Switzerland.
Scott MontgomeryDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Rossella E NappiDepartment of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, Pavia, Italy.
Egon StenagerDepartment of Regional Research, University of Southern Denmark, Odense, Denmark.
Heidi ThompsonSouthern Health & Social Care Trust, Portadown, Northern Ireland.
Zeliha TulekIstanbul University-Cerrahpasa, Florence Nightingale Faculty of Nursing, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Elisabetta Verdun Di CantognoEMD Serono Research & Development Institute, Inc., Billerica, MA, USA.
Manuela SimoniUnit of Endocrinology, Department of Medical Specialties, University Hospital and Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Brigham and Women's Hospital · USIstanbul University-Cerrahpaşa · TRKarolinska Institutet · SEKatholisches Klinikum Bochum · DEOno Pharmaceutical (United States) · USÖrebro University · SEPopulation Council · USRigshospitalet · DKSouthern Health and Social Care Trust · GBUniversity Hospital of Zurich · CHUniversity of California, San Francisco · USUniversity of Modena and Reggio Emilia · ITUniversity of Pavia · ITUniversity of Southern Denmark · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCurrent guidance on the selection of appropriate contraception for people with multiple sclerosis (PwMS) is lacking.

objectiveTo address this gap, an expert-led consensus program developed recommendations to support clinicians in discussing family planning and contraception with women and men with multiple sclerosis (MS).

methodsA multidisciplinary steering committee (SC) of 13 international clinical experts led the program, supported by an extended faculty of 32 experts representing 18 countries. A modified Delphi methodology was used for decision-making and consensus-building. The SC drafted 15 clinical questions focused on patient-centered care, selection of contraception, and timing of stopping/starting contraception and disease-modifying therapies (DMTs). Statements addressing each question were drafted based on evaluation of published evidence and the experts' clinical experience. Consensus was reached if ⩾75% of respondents agreed (scoring 7-9 on a 9-point scale) with each recommendation.

resultsConsensus was reached on 24 of 25 proposed recommendations, including how and when to discuss contraception, types and safety of contraceptives, and how to evaluate the most appropriate contraceptive options for specific patient groups, including those with significant disability or being treated with DMTs.

conclusionThese expert recommendations provide the first practical, relevant, and comprehensive guidance for clinicians on the selection of contraception in PwMS.

Indexed as

ContraceptionMultiple SclerosisConsensusDelphi TechniqueFemaleHumansMaleconsensuscontraceptiondisease-modifying therapyexpert opinionMultiple sclerosisreproductive health

Identifiers

PMID38456514
PMCPMC11363471
OpenAlexW4392588186

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.