ArticleBiomacromolecules2024
Dual-Modified Hyaluronic Acid for Tunable Double Cross-Linked Hydrogel Adhesives.
Article in Biomacromolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Interpretable Machine Learning Insights into Adhesion and Modulus of Biomedical HA-Dopamine Hydrogels.Gels (Basel, Switzerland) · 2026Article
- Biomimetic polymers and their characterization: toward sustainable materials using synthetic biology.Frontiers in chemistry · 2026Review
- Indirect 3D printing in tissue engineering: expanding materials used for improved scaffold functionality.Biomedical engineering online · 2025Review
- The injectable cationic double-crosslinked hydrogel facilitates bone regeneration and repair through sustained antibacterial activity.Materials today. Bio · 2025Article
- An injectable and dual-crosslinked hydrogel for controlled and permanent vascular embolization.Bioactive materials · 2025Article
- The Role of Natural Hydrogels in Enhancing Wound Healing: From Biomaterials to Bioactive Therapies.Pharmaceutics · 2025Review
- Elastic modulus of hyaluronic acid hydrogels by compression testing.Journal of materials science. Materials in medicine · 2025Article
- Enabling Targeted Drug Delivery for Treatment of Ulcerative Colitis with Mucosal-Adhesive Photoreactive Hydrogel.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Evaluation of Articular Cartilage Regeneration Properties of Decellularized Cartilage Powder/Modified Hyaluronic Acid Hydrogel Scaffolds.ACS omega · 2024Article
- Synthesis and Analysis of Novel Hyaluronic Acid-Based Dual Photocrosslinkable Tissue Adhesive: An In Vitro Study.Cureus · 2024Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Conventional techniques for the closure of wounds, such as sutures and staples, have significant drawbacks that can negatively impact wound healing. Tissue adhesives have emerged as promising alternatives, but poor adhesion, low mechanical properties, and toxicity have hindered their widespread clinical adoption. In this work, a dual modified, aldehyde and methacrylate hyaluronic acid (HA) biopolymer (HA-MA-CHO) has been synthesized through a simplified route for use as a double cross-linked network (DCN) hydrogel (HA-MA-CHO-DCN) adhesive for the effective closure and sealing of wounds. HA-MA-CHO-DCN cross-links in two stages: initial cross-linking of the aldehyde functionality (CHO) of HA-MA-CHO using a disulfide-containing cross-linker, 3,3'-dithiobis (propionic hydrazide) (DTPH), leading to the formation of a self-healing injectable gel, followed by further cross-linking via ultraviolet (UV) initiated polymerization of the methacrylate (MA) functionality. This hydrogel adhesive shows a stable swelling behavior and remarkable versatility as the storage modulus (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.