Evidence map›Paper›PMID 38456125›Full record

ArticleBioinformatics advances2024

BioModME for building and simulating dynamic computational models of complex biological systems.

Justin A Womack, Viren Shah, Said H Audi, Scott S Terhune, Ranjan K Dash

Abstract read
In one paragraph

Article in Bioinformatics advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Justin A WomackDepartment of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI 53226, United States.ORCID https://orcid.org/0000-0001-9957-9822
Viren ShahDepartment of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI 53226, United States.
Said H AudiDepartment of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI 53226, United States.
Scott S TerhuneDepartment of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI 53226, United States.
Ranjan K DashDepartment of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI 53226, United States.ORCID https://orcid.org/0000-0001-6751-0679

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Summary: Molecular mechanisms of biological functions and disease processes are exceptionally complex, and our ability to interrogate and understand relationships is becoming increasingly dependent on the use of computational modeling. We have developed "BioModME," a standalone R-based web application package, providing an intuitive and comprehensive graphical user interface to help investigators build, solve, visualize, and analyze computational models of complex biological systems. Some important features of the application package include multi-region system modeling, custom reaction rate laws and equations, unit conversion, model parameter estimation utilizing experimental data, and import and export of model information in the Systems Biology Matkup Language format. The users can also export models to MATLAB, R, and Python languages and the equations to LaTeX and Mathematical Markup Language formats. Other important features include an online model development platform, multi-modality visualization tool, and efficient numerical solvers for differential-algebraic equations and optimization. Availability and implementation: All relevant software information including documentation and tutorials can be found at https://mcw.marquette.edu/biomedical-engineering/computational-systems-biology-lab/biomodme.php. Deployed software can be accessed at https://biomodme.ctsi.mcw.edu/. Source code is freely available for download at https://github.com/MCWComputationalBiologyLab/BioModME.

Identifiers

PMID38456125
PMCPMC10918630

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.