Evidence map›Paper›PMID 38456039›Full record

ArticleRSC chemical biology2024

Reversible oxidative dimerization of 4-thiouridines in tRNA isolates.

Larissa Bessler, Jonathan Groß, Christopher J Kampf, Till Opatz, Mark Helm

Abstract read
In one paragraph

Article in RSC chemical biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Larissa BesslerInstitute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University Mainz Staudingerweg 5 55128 Mainz Germany mhelm@uni-mainz.de.
Jonathan GroßDepartment of Chemistry, Johannes Gutenberg University Mainz Duesbergweg 10-14 55128 Mainz Germany.
Christopher J KampfDepartment of Chemistry, Johannes Gutenberg University Mainz Duesbergweg 10-14 55128 Mainz Germany.ORCID https://orcid.org/0000-0002-8751-5140
Till OpatzDepartment of Chemistry, Johannes Gutenberg University Mainz Duesbergweg 10-14 55128 Mainz Germany.ORCID https://orcid.org/0000-0002-3266-4050
Mark HelmInstitute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University Mainz Staudingerweg 5 55128 Mainz Germany mhelm@uni-mainz.de.ORCID https://orcid.org/0000-0002-0154-0928

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The occurrence of non-canonical nucleoside structures in RNA of biological or synthetic origin has encountered several recent boosts in attention, namely in the context of RNA modifications, and with an eye to RNA vaccines. New nucleoside structures introduce added functionality and function into biopolymers that are otherwise rather homogenous in their chemical structure. Here, we report the discovery of a presumed RNA modification that was identified by combination of liquid chromatography-tandem mass spectrometry (LC-MS/MS) with stable isotope labelling as a dimer of the known RNA modification 4-thiouridine (s

Identifiers

PMID38456039
PMCPMC10915967

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.