Evidence map›Paper›PMID 38455980›Full record

ArticleiScience2024

Placental efflux transporters and antiseizure or antidepressant medication use impact birth weight in MoBa cohort.

Marta H Hernandez, Jacqueline M Cohen, Karoline H Skåra, Thea K Grindstad, Yunsung Lee, Per Magnus, Pål R Njølstad, Ole A Andreassen, Elizabeth C Corfield, Alexandra Havdahl and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Marta H HernandezCentre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
Jacqueline M CohenCentre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
Karoline H SkåraCentre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
Thea K GrindstadCentre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
Yunsung LeeCentre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
Per MagnusCentre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
Pål R NjølstadCenter for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway.
Ole A AndreassenNorwegian Centre for Mental Disorders Research, NORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Elizabeth C CorfieldCenter for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway.
Alexandra HavdahlCenter for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway.
Espen MoldenCenter for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway.
Kari FuruCentre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
Maria C MagnusCentre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
Alvaro HernaezCentre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
Norwegian Institute of Public Health · NOHaukeland University Hospital · NOOslo University Hospital · NOUniversity of Oslo · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Low birth weight raises neonatal risks and lifelong health issues and is linked to maternal medication use during pregnancy. We examined data from the Norwegian Mother, Father, and Child Cohort Study and the Medical Birth Registry of Norway, including 69,828 offspring with genotype data and 81,189 with maternal genotype data. We identified genetic risk variants in placental efflux transporters, calculated genetic scores based on alleles related to transporter activity, and assessed their interaction with prenatal use of antiseizure or antidepressant medication on offspring birth weight. Our study uncovered possible genetic variants in both offspring (rs3740066) and mothers (rs10248420; rs2235015) in placental efflux transporters (MRP2-

Indexed as

Health informaticsHealth sciencesMedical specialtyMedicinePharmacologyPsychiatry

Identifiers

PMID38455980
PMCPMC10918264
OpenAlexW4391957723

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.