Evidence map›Paper›PMID 38455403›Full record

ArticleAmerican journal of cancer research2024

"Tumor Treating Fields" delivered via electromagnetic induction have varied effects across glioma cell lines and electric field amplitudes.

Rea Ravin, Teddy X Cai, Aiguo Li, Nicole Briceno, Randall H Pursley, Marcial Garmendia-Cedillos, Tom Pohida, Herui Wang, Zhengping Zhuang, Jing Cui and 4 more

Abstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of cancer research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Rea RavinSection on Quantitative Imaging and Tissue Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH Bethesda, Maryland, USA.
Teddy X CaiSection on Quantitative Imaging and Tissue Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH Bethesda, Maryland, USA.
Aiguo LiNeuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH Bethesda, Maryland, USA.
Nicole BricenoNeuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH Bethesda, Maryland, USA.
Randall H PursleyInstrumentation Development and Engineering Applications Section, National Institute of Biomedical Imaging and Bioengineering, NIH Bethesda, Maryland, USA.
Marcial Garmendia-CedillosInstrumentation Development and Engineering Applications Section, National Institute of Biomedical Imaging and Bioengineering, NIH Bethesda, Maryland, USA.
Tom PohidaInstrumentation Development and Engineering Applications Section, National Institute of Biomedical Imaging and Bioengineering, NIH Bethesda, Maryland, USA.
Herui WangNeuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH Bethesda, Maryland, USA.
Zhengping ZhuangNeuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH Bethesda, Maryland, USA.
Jing CuiNeuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH Bethesda, Maryland, USA.
Nicole Y MorganTrans-NIH Shared Resources on Biomedical Engineering and Physical Sciences, National Institute of Biomedical Imaging and Bioengineering, NIH Bethesda, Maryland, USA.
Nathan H WilliamsonSection on Quantitative Imaging and Tissue Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH Bethesda, Maryland, USA.
Mark R GilbertNeuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH Bethesda, Maryland, USA.
Peter J BasserSection on Quantitative Imaging and Tissue Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH Bethesda, Maryland, USA.

Funding

Hypoxia signaling in cancer developmentZIABC011773 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI ZHUANG, ZHENGPING · 2017 to 2025
$13.0M
Microfabrication for Biomedical ResearchZICEB000012 · NIBIB · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · PI MORGAN, NICOLE Y · 2010 to 2025
$11.3M
Bioinformatics: Characterizing Brain Tumor DateZIABC011784 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GILBERT, MARK · 2017 to 2024
$4.9M
Instrumentation Development and Engineering Application Solutions (IDEAS) Shared ResourceZICEB000103 · NIBIB · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · PI POHIDA, THOMAS · 2024 to 2025
$2.4M
6 · The paper itself

Abstract

Previous studies reported that alternating electric fields (EFs) in the intermediate frequency (100-300 kHz) and low intensity (1-3 V/cm) regime - termed "Tumor Treating Fields" (TTFields) - have a specific, anti-proliferative effect on glioblastoma multiforme (GBM) cells. However, the mechanism(s) of action remain(s) incompletely understood, hindering the clinical adoption of treatments based on TTFields. To advance the study of such treatment

Indexed as

alternating electric fieldselectromagnetic inductiongene expressionGlioblastoma multiforme (GBM)tumor treating fields

Identifiers

PMID38455403
PMCPMC10915321

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.