Evidence map›Paper›PMID 38455399›Full record

ArticleAmerican journal of cancer research2024

SPATA20 deficiency enhances the metastatic and angiogenic potential of cancer cells by promoting HIF-1α synthesis.

Sanga Choi, Seongkyeong Yoo, Miyeon Jeon, Soohyun Park, Yunsup Choi, Jiyeon An, Sungmi Jeon, Mingyu Lee, Jang-Hyuk Yun, Jong-Wan Park and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of cancer research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Sanga ChoiDepartment of Pharmacology and Program in Biomedical Science and Engineering, Inha University College of Medicine Incheon 22212, South Korea.
Seongkyeong YooDepartment of Pharmacology and Program in Biomedical Science and Engineering, Inha University College of Medicine Incheon 22212, South Korea.
Miyeon JeonDepartment of Pharmacology and Program in Biomedical Science and Engineering, Inha University College of Medicine Incheon 22212, South Korea.
Soohyun ParkDepartment of Pharmacology and Program in Biomedical Science and Engineering, Inha University College of Medicine Incheon 22212, South Korea.
Yunsup ChoiDepartment of Pharmacology and Program in Biomedical Science and Engineering, Inha University College of Medicine Incheon 22212, South Korea.
Jiyeon AnDepartment of Pharmacology and Program in Biomedical Science and Engineering, Inha University College of Medicine Incheon 22212, South Korea.
Sungmi JeonDepartment of Plastic and Reconstructive Surgery, Seoul National University Hospital, Seoul National University College of Medicine Seoul 03080, South Korea.
Mingyu LeeDivision of Allergy and Clinical Immunology, Brigham and Women's Hospital and Department of Medicine, Harvard Medical School Boston, MA 02115, USA.
Jang-Hyuk YunCollege of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University Chuncheon 24341, South Korea.
Jong-Wan ParkDepartment of Pharmacology, Seoul National University College of Medicine Seoul 03080, South Korea.
Iljin KimDepartment of Pharmacology and Program in Biomedical Science and Engineering, Inha University College of Medicine Incheon 22212, South Korea.
Inha University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypoxia-inducible factors (HIFs) regulate cellular oxygen balance and play a central role in cancer metastasis and angiogenesis. Despite extensive research on HIFs, successful therapeutic strategies remain limited due to the intricate nature of their regulation. In this study, we identified SPATA20, a relatively understudied protein with a thioredoxin-like domain, as an upstream regulator of HIF-1α. Depleting SPATA20 induced HIF-1α expression, suggesting a tumor-suppressive role for SPATA20 in cancer cells. SPATA20 depletion increased HIF-1α protein levels and transcriptional activity without affecting its degradation. It appears that SPATA20 inhibits the

Indexed as

cancerHIF-1αhypoxiaSPATA20

Identifiers

PMID38455399
PMCPMC10915324
OpenAlexW4394763398

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.