Evidence map›Paper›PMID 38455317›Full record

ArticleFrontiers in epidemiology2022

RTS,S vaccination is associated with reduced parasitemia and anemia among children diagnosed with malaria in the outpatient department of a district hospital in rural Malawi.

Jacob L Todd, Hillary M Topazian, Madalitso Zulu, Pilirani Mafunga, Clement Mapanje, James G Kaphatika, Maganizo B Chagomerana, Irving Hoffman, Jonathan J Juliano, Tisungane Mvalo

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 77% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Jacob L ToddInstitute for Global Health and Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Hillary M TopazianMRC Centre for Global Infectious Disease Analysis, Imperial College London, London, United Kingdom.
Madalitso ZuluUniversity of North Carolina Project Malawi, Lilongwe, Malawi.
Pilirani MafungaMalaria Alert Centre, Kamuzu University of Health Sciences, Blantyre, Malawi.
Clement MapanjeUniversity of North Carolina Project Malawi, Lilongwe, Malawi.
James G KaphatikaUniversity of North Carolina Project Malawi, Lilongwe, Malawi.
Maganizo B ChagomeranaDepartment of Medicine, Institute for Global Health and Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Irving HoffmanDepartment of Medicine, Institute for Global Health and Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Jonathan J JulianoDivision of Infectious Diseases, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, United States.
Tisungane MvaloDepartment of Pediatrics, Institute for Global Health and Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
University of North Carolina at Chapel Hill · USUniversity of Malawi · MWImperial College London · GBKamuzu Central Hospital · MW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The RTS,S/AS01 malaria vaccine was recently approved by the World Health Organization, but real-world effectiveness is still being evaluated. We measured hemoglobin concentration and parasite density in vaccinated and unvaccinated children who had been diagnosed with malaria by rapid diagnostic test (mRDT) in the outpatient department of a rural hospital in Malawi. Considering all mRDT positive participants, the mean hemoglobin concentration among unvaccinated participants was 9.58 g/dL. There was improvement to 9.82 g/dL and 10.36 g/dL in the 1 or 2 dose group (

Indexed as

anemiamalariaMalawiparasite densityparasitemiaRTS,Svaccine

Identifiers

PMID38455317
PMCPMC10910957
OpenAlexW4310039995

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.