Evidence map›Paper›PMID 38455314›Full record

ArticleFrontiers in epidemiology2022

Low Complexity of Infection Is Associated With Molecular Persistence of

Hillary M Topazian, Kara A Moser, Billy Ngasala, Peter O Oluoch, Catherine S Forconi, Lwidiko E Mhamilawa, Ozkan Aydemir, Oksana Kharabora, Molly Deutsch-Feldman, Andrew F Read and 11 more

Open access · diamondAbstract read
In one paragraph

Article in Frontiers in epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Detection of novelMicrobial genomics · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 9 institutions in 6 countries.

Hillary M TopazianDepartment of Infectious Disease Epidemiology, Imperial College, London, United Kingdom.
Kara A MoserInstitute for Global Health and Infectious Diseases, University of North Carolina, Chapel Hill, NC, United States.
Billy NgasalaDepartment of Parasitology and Medical Entomology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Peter O OluochDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, United States.
Catherine S ForconiDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, United States.
Lwidiko E MhamilawaDepartment of Parasitology and Medical Entomology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Ozkan AydemirDepartment of Pathology and Laboratory Medicine, Brown University, Providence, RI, United States.
Oksana KharaboraInstitute for Global Health and Infectious Diseases, University of North Carolina, Chapel Hill, NC, United States.
Molly Deutsch-FeldmanDepartment of Epidemiology, Gillings School of Global Public Health, Chapel Hill, NC, United States.
Andrew F ReadDepartment of Entomology, Penn State University, University Park, PA, United States.
Madeline DentonInstitute for Global Health and Infectious Diseases, University of North Carolina, Chapel Hill, NC, United States.
Antonio LorenzoDepartment of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON, Canada.
Nicole MideoDepartment of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON, Canada.
Bernhards OgutuCenter for Global Health Research, Kenyan Medical Research Institute, Kisumu, Kenya.
Ann M MoormannDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, United States.
Andreas MårtenssonDepartment of Women's and Children's Health, International Maternal and Child Health, Uppsala University, Uppsala, Sweden.
Boaz OdwarCenter for Global Health Research, Kenyan Medical Research Institute, Kisumu, Kenya.
Jeffrey A BaileyDepartment of Pathology and Laboratory Medicine, Brown University, Providence, RI, United States.
Hoseah AkalaCenter for Global Health Research, Kenyan Medical Research Institute, Kisumu, Kenya.
John Michael Ong'echaCenter for Global Health Research, Kenyan Medical Research Institute, Kisumu, Kenya.
Jonathan J JulianoInstitute for Global Health and Infectious Diseases, University of North Carolina, Chapel Hill, NC, United States.
University of North Carolina at Chapel Hill · USKenya Medical Research Institute · KEUniversity of Massachusetts Chan Medical School · USBrown University · USUniversity of Toronto · CAUppsala University · SEImperial College London · GBMuhimbili University of Health and Allied Sciences · TZPennsylvania State University · US

Funding

Mentoring in Translational Malaria GenomicsK24AI134990 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Jonathan J Juliano · 2018 to 2026
$1.6M
NIAID NIH HHS K24 AI134990
6 · The paper itself

Abstract

Background: Methods: Three hundred children aged 2-10 years with uncomplicated Results: While there was a broad range of clearance rates at both sites, 85% and 96% of Kenyan and Tanzanian samples, respectively, were qPCR-positive but microscopy-negative at 72 h post-treatment. A greater complexity of infection (COI) was negatively associated with qPCR-detectable parasitemia at 72 h (OR: 0.70, 95% CI: 0.53-0.94), and a greater baseline parasitemia was marginally associated with qPCR-detectable parasitemia (1,000 parasites/uL change, OR: 1.02, 95% CI: 1.01-1.03). Demographic, serological, and host genotyping characteristics showed no association with qPCR-detectable parasitemia at 72 h. Parasite haplotype-specific clearance slopes were grouped around the mean with no association detected between specific haplotypes and slower clearance rates. Conclusions: Identifying risk factors for slow clearing

Indexed as

artemisininartemisinin combination therapyKenyaparasite clearanceP. falciparumPlasmodiumTanzania

Identifiers

PMID38455314
PMCPMC10910917
OpenAlexW4281671078

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.