ArticleWorld journal of stem cells2024
High quality repair of osteochondral defects in rats using the extracellular matrix of antler stem cells.
Article in World journal of stem cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Natural Biomaterials for Osteochondral Repair: From Source to Strategy.Advanced healthcare materials · 2026Review
- TheBiology · 2025Article
- Advancements in Stem Cell Applications for Livestock Research: A Review.Veterinary sciences · 2025Review
- Dual-network hydrogel loaded with antler stem cells conditioned medium and EGCG promotes diabetic wound healing through antibacterial, antioxidant, anti-inflammatory, and angiogenesis.Materials today. Bio · 2025Article
- Deer antler stem cell niche: An interesting perspective.World journal of stem cells · 2024Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCartilage defects are some of the most common causes of arthritis. Cartilage lesions caused by inflammation, trauma or degenerative disease normally result in osteochondral defects. Previous studies have shown that decellularized extracellular matrix (ECM) derived from autologous, allogenic, or xenogeneic mesenchymal stromal cells (MSCs) can effectively restore osteochondral integrity.
aimTo determine whether the decellularized ECM of antler reserve mesenchymal cells (RMCs), a xenogeneic material from antler stem cells, is superior to the currently available treatments for osteochondral defects.
methodsWe isolated the RMCs from a 60-d-old sika deer antler and cultured them
resultsThe defects were successfully repaired by applying the ECM-sheets. The highest quality of repair was achieved in the RMC-ECM group both
conclusionDecellularized xenogeneic ECM derived from the antler stem cell, particularly the active form (RMC-ECM), can achieve high quality repair/reconstruction of osteochondral defects, suggesting that selection of decellularized ECM for such repair should be focused more on bioactivity rather than kinship.
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