Evidence map›Paper›PMID 38455013›Full record

ReviewChemical science2024

The intricate link between membrane lipid structure and composition and membrane structural properties in bacterial membranes.

Tzong-Hsien Lee, Patrick Charchar, Frances Separovic, Gavin E Reid, Irene Yarovsky, Marie-Isabel Aguilar

Open access · diamondAbstract readReview
In one paragraph

Review in Chemical science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
18.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 79 citations in OpenAlex.

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  14. Proanthocyanidins inhibit methicillin-resistantCurrent research in food science · 2026
    Article
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  18. A distinct subpopulation of membrane vesicles inApplied and environmental microbiology · 2025
    Article
  19. Phylogenetic Aspects of Higher Plant Lipid Fatty Acid Profile.International journal of molecular sciences · 2025
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Tzong-Hsien LeeDepartment of Biochemistry and Molecular Biology, Monash University Clayton VIC 3800 Australia mibel.aguilar@monash.edu.ORCID https://orcid.org/0009-0008-6651-3729
Patrick CharcharSchool of Engineering, RMIT University Melbourne Victoria 3001 Australia.ORCID https://orcid.org/0000-0002-9201-4711
Frances SeparovicSchool of Chemistry, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne VIC 3010 Australia.ORCID https://orcid.org/0000-0002-6484-2763
Gavin E ReidSchool of Chemistry, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne VIC 3010 Australia.ORCID https://orcid.org/0000-0002-9675-1444
Irene YarovskySchool of Engineering, RMIT University Melbourne Victoria 3001 Australia.ORCID https://orcid.org/0000-0002-4033-5150
Marie-Isabel AguilarDepartment of Biochemistry and Molecular Biology, Monash University Clayton VIC 3800 Australia mibel.aguilar@monash.edu.ORCID https://orcid.org/0000-0002-0234-4064
Monash University · AURMIT University · AUThe University of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is now evident that the cell manipulates lipid composition to regulate different processes such as membrane protein insertion, assembly and function. Moreover, changes in membrane structure and properties, lipid homeostasis during growth and differentiation with associated changes in cell size and shape, and responses to external stress have been related to drug resistance across mammalian species and a range of microorganisms. While it is well known that the biomembrane is a fluid self-assembled nanostructure, the link between the lipid components and the structural properties of the lipid bilayer are not well understood. This perspective aims to address this topic with a view to a more detailed understanding of the factors that regulate bilayer structure and flexibility. We describe a selection of recent studies that address the dynamic nature of bacterial lipid diversity and membrane properties in response to stress conditions. This emerging area has important implications for a broad range of cellular processes and may open new avenues of drug design for selective cell targeting.

Identifiers

PMID38455013
PMCPMC10915831
OpenAlexW4391377832

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.