Evidence map›Paper›PMID 38454918›Full record

ArticleSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society2024

The effect of mephedrone on human neuroblastoma and astrocytoma cells.

Ibrahim M Alanazi, Abdullah R Alzahrani, Mohammad A Alsaad, Abdulaziz L Moqeem, Abdulmohsen M Hamdi, Mohiuddin M Taher, David G Watson, M Helen Grant

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Ibrahim M AlanaziDepartment of Pharmacology and Toxicology, College of Medicine, Umm Al-Qura University, Al-Abidiyah, P.O.Box 13578, Makkah 21955, Saudi Arabia.
Abdullah R AlzahraniDepartment of Pharmacology and Toxicology, College of Medicine, Umm Al-Qura University, Al-Abidiyah, P.O.Box 13578, Makkah 21955, Saudi Arabia.
Mohammad A AlsaadDepartment of Parasitology, College of Medicine, Umm AL Qura University, Al-Abidiyah, P.O.Box 13578, Makkah 21955, Saudi Arabia.
Abdulaziz L MoqeemHome Health Care,Directorate of Health Affairs Jeddah, Ministry of Health, P.O.Box11176, Ryiadh, Saudi Arabia.
Abdulmohsen M HamdiHome Health Care,Directorate of Health Affairs Jeddah, Ministry of Health, P.O.Box11176, Ryiadh, Saudi Arabia.
Mohiuddin M TaherScience and Technology Unit, Deanship of Scientific Research, and Department of Medical Genetics, College of Medicine, Umm-Al-Qura University, Makkah, Saudi Arabia.
David G WatsonStrathclyde Institute of Pharmacy & Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, UK.
M Helen GrantDepartment of Biomedical Engineering, University of Strathclyde, Glasgow G4 0NW, UK.
Umm al-Qura University · SAMinistry of Health · SAUniversity of Strathclyde · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mephedrone is an illegal drug that is used recreationally. Few studies have been conducted to investigate the mechanisms by which mephedrone is harming cells. In this research, we investigated the effect of mephedrone using toxicology coupled with LC-MS/MS based metabolomics in the two CNS derived cell lines. Methods of assessment such as neutral red (NR) assay, dimethylthiazolyl diphenyltetrazolium bromide (MTT), lactose dehydrogenase (LDH) measurement, and morphology were performed to identify the effect on cell viability and to identify the best concentration to be used in a metabolomics study. A concentration of 100

Indexed as

GlutathioneLC-MS/MSMephedroneMetabolomics

Identifiers

PMID38454918
PMCPMC10918268
OpenAlexW4392244892

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.