Evidence map›Paper›PMID 38454907›Full record

ReviewFrontiers in human neuroscience2024

Management of essential tremor deep brain stimulation-induced side effects.

Alfonso Enrique Martinez-Nunez, Filipe P Sarmento, Vyshak Chandra, Christopher William Hess, Justin David Hilliard, Michael S Okun, Joshua K Wong

Abstract readReview
In one paragraph

Review in Frontiers in human neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Probabilistic mapping of tremor control and gait ataxia risk in deep brain stimulation.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Article
  3. Article
  4. Natural disease progression vs. DBS-related worsening in essential tremor.medRxiv : the preprint server for health sciences · 2025
    Article
  5. Deep Brain Stimulation in Classical Galactosemia: A Case-Report.Movement disorders clinical practice · 2025
    Article
  6. Review
  7. Responsive Deep Brain Stimulation: A New Hope for Controlling Stimulation-Induced Dysarthria in Essential Tremor.Movement disorders : official journal of the Movement Disorder Society · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alfonso Enrique Martinez-NunezNorman Fixel Institute for Neurological Diseases, Gainesville, FL, United States.
Filipe P SarmentoNorman Fixel Institute for Neurological Diseases, Gainesville, FL, United States.
Vyshak ChandraDepartment of Neurosurgery, University of Florida, Gainesville, FL, United States.
Christopher William HessNorman Fixel Institute for Neurological Diseases, Gainesville, FL, United States.
Justin David HilliardNorman Fixel Institute for Neurological Diseases, Gainesville, FL, United States.
Michael S OkunNorman Fixel Institute for Neurological Diseases, Gainesville, FL, United States.
Joshua K WongNorman Fixel Institute for Neurological Diseases, Gainesville, FL, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Deep brain stimulation (DBS) is an effective surgical therapy for carefully selected patients with medication refractory essential tremor (ET). The most popular anatomical targets for ET DBS are the ventral intermedius nucleus (VIM) of the thalamus, the caudal zona incerta (cZI) and the posterior subthalamic area (PSA). Despite extensive knowledge in DBS programming for tremor suppression, it is not uncommon to experience stimulation induced side effects related to DBS therapy. Dysarthria, dysphagia, ataxia, and gait impairment are common stimulation induced side effects from modulation of brain tissue that surround the target of interest. In this review, we explore current evidence about the etiology of stimulation induced side effects in ET DBS and provide several evidence-based strategies to troubleshoot, reprogram and retain tremor suppression.

Indexed as

ataxiadeep brain stimulationdysarthriadysphagiagait impairment

Identifiers

PMID38454907
PMCPMC10918853

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.