Antibiomania: A Case Report of a Manic Episode Potentially Induced by the Interaction of Clarithromycin and Amoxicillin during H. Pylori Eradication Therapy.

Juan Pablo Carrasco, Eduardo Jesús Aguilar

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In one paragraph

Article in Actas espanolas de psiquiatria, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.4field-weighted citation impact, top 38% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Juan Pablo CarrascoDepartment of Psychiatry, Hospital Clínico Universitario de Valencia, 46010 Valencia, Spain; Biomedical Research Institute INCLIVA, 46010 Valencia, Spain.

Eduardo Jesús AguilarDepartment of Psychiatry, Hospital Clínico Universitario de Valencia, 46010 Valencia, Spain; Biomedical Research Institute INCLIVA, 46010 Valencia, Spain; Department of Psychiatry, Faculty of Medicine of Valencia, 46010 Valencia, Spain; Biomedical Research Networking Centre in Mental Health (CIBERSAM), 28029 Madrid, Spain.

Hospital Clínico Universitario de Valencia · ESINCLIVA Health Research Institute · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antibiomanic episodes, or as the DSM-5 refers to them, drug-induced manic episodes, pose a clinical challenge that is still poorly understood. There is insufficient information on the most common clinical presentation, patient profile, or underlying aetiopathogenic mechanisms. We present the clinical case of a 67-year-old woman who, after starting treatment (clarithromycin and amoxicillin) for the eradication of Helicobacter pylori, bacteria presented with a brief manic episode, which resolved after withdrawal of both drugs and with antipsychotic treatment. The possible interaction of both drugs, as GABA antagonists, in the generation of such episodes is discussed, and the clinical importance of such episodes in psychiatric emergency departments and liaison and interconsultation psychiatry, is highlighted.

Indexed as

Helicobacter InfectionsHelicobacter pyloriAgedAmoxicillinAnti-Bacterial AgentsClarithromycinDrug Therapy, CombinationFemaleHumansManiaTreatment OutcomeAmoxicillinAnti-Bacterial AgentsClarithromycin

Identifiers

PMID38454894

PMCPMC10926010

OpenAlexW4394739685

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.