ArticleThe Journal of clinical endocrinology and metabolism2024
Prospective Multicenter Registry-Based Study on Thyroid Storm: The Guidelines for Management From Japan Are Useful.
Article in The Journal of clinical endocrinology and metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Management of thyroid emergencies: joint consensus statement on management of thyroid storm.European thyroid journal · 2026Review
- Prognostic factors and prognostic risk score of 30-day all-cause mortality in thyroid storm.BMC endocrine disorders · 2026Article
- Approach to the patient with severe hyperthyroidism-related complications.The Journal of clinical endocrinology and metabolism · 2026Review
- Determinants of diagnostic delay in thyroid storm: a 12-year single-center cohort study.Journal of the Endocrine Society · 2026Article
- Approach to the patient with thyroid storm.The Journal of clinical endocrinology and metabolism · 2026Review
- Delayed Diagnosis of Thyroid Storm Presenting With Predominant Gastrointestinal Symptoms.Cureus · 2026Article
- From Functional Disorder to a Life-Threatening Emergency: A Rare Adolescent Case of Thyrotoxicosis.Cureus · 2026Article
- Plasmapheresis for the treatment of thyroid storm.Endocrinology, diabetes & metabolism case reports · 2025Article
- Rectal thionamide administration in the setting of thyroid storm: a case report and review of the literature.Endocrinology, diabetes & metabolism case reports · 2024Article
- Preoperative Preparation in Hyperthyroidism and Surgery in the Hyperthyroid State.Sisli Etfal Hastanesi tip bulteni · 2024Review
- Thyrotoxicosis due to Gestational Trophoblastic Disease: Unmet Needs in the Management of Gestational Thyrotoxicosis.Case reports in endocrinology · 2024Article
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Authors and funding
15 authors.
Funding
Abstract
contextThe mortality rate in thyroid storm (TS) has been reported to be higher than 10%.
objectiveWe aimed to evaluate the effectiveness of the 2016 guidelines for the management of TS proposed by the Japan Thyroid Association and Japan Endocrine Society.
methodsIn this prospective multicenter registry-based study, patients with new-onset TS were registered in the Research Electronic Data Capture (REDCap), a secure web platform. On day 30 after admission, clinical information and prognosis of each patient were added to the platform. On day 180, the prognosis was described.
resultsThis study included 110 patients with TS. The median of Acute Physiology and Chronic Health Evaluation (APACHE) II score was 13, higher than the score (10) in the previous nationwide epidemiological study (P = .001). Nonetheless, the mortality rate at day 30 was 5.5%, approximately half compared with 10.7% in the previous nationwide survey. Lower body mass index, shock, and lower left ventricular ejection fraction were positively associated with poor prognosis at day 30, while the lack of fever ≥ 38 °C was related to the outcome. The mortality rate in patients with an APACHE II score ≥ 12 for whom the guidelines were not followed was significantly higher than the rate in patients for whom the guidelines were followed (50% vs 4.7%) (P = .01).
conclusionPrognosis seemed better than in the previous nationwide survey, even though disease severity was higher. The mortality rate was lower when the guidelines were followed. Thus, the guidelines are useful for managing TS.
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