Evidence map›Paper›PMID 38454546›Full record

ArticleJournal of diabetes science and technology2024

Evaluation of a Protocol Change Promoting Lactated Ringers Over Normal Saline in the Treatment of Diabetic Ketoacidosis.

Jake Johnson, Andjela Drincic, Emma Buddenhagen, Kaitlyn Nein, Kaeli Samson, Trek Langenhan

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Article in Journal of diabetes science and technology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jake JohnsonDivision of Diabetes, Endocrine, and Metabolism, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA.ORCID 0009-0003-9821-0654
Andjela DrincicDivision of Diabetes, Endocrine, and Metabolism, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA.ORCID 0000-0001-8365-7662
Emma BuddenhagenCollege of Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
Kaitlyn NeinCollege of Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
Kaeli SamsonDepartment of Biostatistics, University of Nebraska Medical Center, Omaha, NE, USA.
Trek LangenhanDivision of Hospital Medicine, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCurrent guidelines recommend normal saline (NS) for fluid resuscitation in the management of patients presenting with diabetic ketoacidosis (DKA). However, previous prospective studies have demonstrated improvement in patient-specific outcomes, including time to DKA resolution, when balanced crystalloid fluids are used.

methodsWe conducted a single institution, retrospective cohort study of adult patients admitted with DKA before and after a protocol change within our institution, which shifted the default resuscitative and maintenance fluid in our DKA management protocol from NS to lactated Ringer's solution (LR). The primary outcome was time from DKA clinical presentation until DKA resolution. The secondary outcome was time to discontinuation of DKA protocol insulin drip.

resultsOf 246 patients meeting inclusion criteria, 119 were in the NS group (preprotocol change, where NS was the default resuscitative fluid) and 127 to the LR group (postprotocol change, where LR was the default resuscitative fluid). Time to DKA resolution was significantly decreased in the LR group (mean = 17.1 hours; standard deviation [

conclusionsIn this retrospective cohort study, protocolized DKA intravenous fluid management with LR resulted in shorter time to resolution of DKA and reduced duration of DKA protocol insulin drip.

Indexed as

Diabetic KetoacidosisFluid TherapyRinger's LactateSaline SolutionAdultClinical ProtocolsFemaleHumansInsulinMaleMiddle AgedRetrospective StudiesTreatment OutcomeInsulinRinger's LactateSaline Solutiondiabetic ketoacidosisDKADKA treatmentfluid selection DKAlactated ringers

Identifiers

PMID38454546
PMCPMC11089871

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.