Evidence map›Paper›PMID 38454527›Full record

ArticleIMA fungus2024

Galleria mellonella in vitro model for chromoblastomycosis shows large differences in virulence between isolates.

Dongmei Shi, Zhiya Yang, Wanqing Liao, Chen Liu, Liang Zhao, Huilin Su, Xiaodong Wang, Huan Mei, Min Chen, Yinggai Song and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in IMA fungus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Virulence ofVirulence · 2026
    Article
  2. Article
  3. Article
  4. DecipheringMicrobiology spectrum · 2025
    Article
  5. Journal of fungi (Basel, Switzerland) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Dongmei Shi *Department of Dermatology & Laboratory of Medical Mycology, Jining No. 1 People's Hospital, Shandong, China.
Zhiya Yang *The Laboratory of Medical Mycology, Jining No. 1 People's Hospital, Shandong, China.
Wanqing LiaoDepartment of Dermatology, Shanghai Key Laboratory of Molecular Medical Mycology, Changzheng Hospital, Shanghai, China.
Chen LiuThe Laboratory of Medical Mycology, Jining No. 1 People's Hospital, Shandong, China.
Liang ZhaoKey Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education of Guizhou & Guizhou Talent Base for Microbiology and Human Health, School of Basic Medical Sciences, Guizhou Medical University, Guiyang, China.
Huilin SuDepartment of Dermatology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Xiaodong WangDepartment of Dermatology, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Huan MeiInstitute of Dermatology, Chinese Academy of Medical Science, Nanjing, China.
Min ChenDepartment of Dermatology, Shanghai Key Laboratory of Molecular Medical Mycology, Changzheng Hospital, Shanghai, China.
Yinggai SongDepartment of Dermatology and Venereology, First Hospital in Peking University, Beijing, China.
Sybren de Hoog *Center of Expertise in Mycology of Radboud University Medical Center, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands. sybren.dehoog@radboudumc.nl.
Shuwen Deng *Department of Medical Microbiology, The People's Hospital of Suzhou New District, Suzhou, Jiangsu, China. danyanghhh@qq.com.

Funding

National Natural Science Foundation of China 81720108026Suzhou Bureau of Science and Technology SKY2022037
6 · The paper itself

Abstract

backgroundChromoblastomycosis is the World Health Organization (WHO)-recognized fungal implantation disease that eventually leads to severe mutilation. Cladophialophora carrionii (C. carrionii) is one of the agents. However, the pathogenesis of C. carrionii is not fully investigated yet.

methodsWe investigated the pathogenic potential of the fungus in a Galleria mellonella (G. mellonella) larvae infection model. Six strains of C. carrionii, and three of its environmental relative C. yegresii were tested. The G. mellonella model was also applied to determine antifungal efficacy of amphotericin B, itraconazole, voriconazole, posaconazole, and terbinafine.

resultsAll strains were able to infect the larvae, but virulence potentials were strain-specific and showed no correlation with clinical background of the respective isolate. Survival of larvae also varied with infection dose, and with growth speed and melanization of the fungus. Posaconazole and voriconazole exhibited best activity against Cladophialophora, followed by itraconazole and terbinafine, while limited efficacy was seen for amphotericin B.

conclusionInfection behavior deviates significantly between strains. In vitro antifungal susceptibility of tested strains only partly explained the limited treatment efficacy in vivo.

Indexed as

Antifungal efficacy in vivoChromoblastomycosisCladophialophora carrioniiGalleria mellonellaVirulence

Identifiers

PMID38454527
PMCPMC10921731

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.