Evidence map›Paper›PMID 38454475›Full record

ArticleRespiratory research2024

MUC5AC concentrations in lung lavage fluids are associated with acute lung injury after cardiac surgery.

Judith van Paassen, Pieter S Hiemstra, Abraham C van der Linden, Evert de Jonge, Jaap Jan Zwaginga, Robert J M Klautz, M Sesmu Arbous

Open access · goldAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Judith van PaassenDepartment of Intensive Care, Leiden University Medical Center, Albinusdreef 2, Leiden, B4-57, 2333 ZA, the Netherlands. j.van_paassen@lumc.nl.
Pieter S HiemstraDepartment of Pulmonology, Leiden University Medical Centre, Leiden, the Netherlands.
Abraham C van der LindenDepartment of Pulmonology, Leiden University Medical Centre, Leiden, the Netherlands.
Evert de JongeDepartment of Intensive Care, Leiden University Medical Center, Albinusdreef 2, Leiden, B4-57, 2333 ZA, the Netherlands.
Jaap Jan ZwagingaCenter for Clinical Transfusion Research, Sanquin Research, Leiden, the Netherlands.
Robert J M KlautzDepartment of Thoracic Surgery, Leiden University Medical Center, Leiden, the Netherlands.
M Sesmu ArbousDepartment of Intensive Care, Leiden University Medical Center, Albinusdreef 2, Leiden, B4-57, 2333 ZA, the Netherlands.
Leiden University Medical Center · NLLeiden University · NLSanquin · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heart surgery may be complicated by acute lung injury and adult respiratory distress syndrome. Expression and release of mucins MUC5AC and MUC5B in the lungs has been reported to be increased in acute lung injury. The aim of our study was to [1] investigate the perioperative changes of MUC5AC, MUC5B and other biomarkers in mini-bronchoalveolar lavage (minBAL), and [2] relate these to clinical outcomes after cardiac surgery. In this prospective cohort study in 49 adult cardiac surgery patients pre- and post-surgery non-fiberscopic miniBAL fluids were analysed for MUC5AC, MUC5B, IL-8, human neutrophil elastase, and neutrophils. All measured biomarkers increased after surgery. Perioperative MUC5AC-change showed a significant negative association with postoperative P/F ratio (p = 0.018), and a positive association with ICU stay (p = 0.027). In conclusion, development of lung injury after cardiac surgery and prolonged ICU stay are associated with an early increase of MUC5AC as detected in mini-BAL.

Indexed as

Acute Lung InjuryCardiac Surgical ProceduresAdultBiomarkersBronchoalveolar Lavage FluidHumansMucin 5ACProspective StudiesBiomarkersMUC5AC protein, humanMucin 5ACARDSCardiac surgeryIntensive careMucinsPerioperative carePulmonary biomarkers

Identifiers

PMID38454475
PMCPMC10921709
OpenAlexW4392550028

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.