Evidence map›Paper›PMID 38454311›Full record

ArticleObesity (Silver Spring, Md.)2024

Inverse associations of cord blood mitochondrial DNA copy number with childhood adiposity.

Aalekhya Reddam, Tessa R Bloomquist, Lindsey T Covell, Heng Hu, Sharon E Oberfield, Dympna Gallagher, Rachel L Miller, Jeff Goldsmith, Andrew G Rundle, Andrea A Baccarelli and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity (Silver Spring, Md.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
3.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Aalekhya ReddamDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA.ORCID 0000-0001-5616-1223
Tessa R BloomquistDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA.
Lindsey T CovellDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA.
Heng HuDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA.
Sharon E OberfieldDepartment of Pediatrics, New York-Presbyterian Hospital, Columbia University Medical Center, New York, New York, USA.
Dympna GallagherNutrition Obesity Research Center, Columbia University Medical Center, New York, New York, USA.ORCID 0000-0003-1769-9754
Rachel L MillerDivision of Clinical Immunology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Jeff GoldsmithDepartment of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York, USA.
Andrew G RundleDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA.
Andrea A BaccarelliDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA.
Julie B HerbstmanDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA.
Allison KupscoDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA.
Columbia University · USColumbia University Irving Medical Center · USIcahn School of Medicine at Mount Sinai · USNewYork–Presbyterian Hospital · US

Funding

True Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MATTHEW S PERZANOWSKI · 1998 to 2026
$44.7M
Urban Diesel Exposure and Inner City AsthmaR01ES013163 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MILLER, RACHEL L · 2005 to 2016
$6.5M
Pre- and Postnatal PBDE Exposure, Thyroid Hormones, and NeurodevelopmentR01ES021806 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HERBSTMAN, JULIE BETH · 2012 to 2016
$2.6M
Prenatal Exposures to Flame-Retardants: Mitochondrial Signatures and Childhood ObesityR00ES030749 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KUPSCO, ALLISON · 2021 to 2023
$639k
NIEHS NIH HHS P30 ES009089NIEHS NIH HHS P30ES009089NIEHS NIH HHS R00 ES030749NIEHS NIH HHS R00ES030749NIEHS NIH HHS R01 ES013163NIEHS NIH HHS R01 ES021806NIEHS NIH HHS R01ES021806NIEHS NIH HHS R01ES13163
6 · The paper itself

Abstract

objectiveThe objective of this study was to examine associations between umbilical cord mitochondrial DNA copy number (mtDNAcn) and adiposity across childhood.

methodsIn a prospective birth cohort of Dominican and African American children from New York City, New York (1998-2006), mtDNAcn was measured in cord blood. Children (N = 336) were evaluated for their height, weight, and bioimpedance at age 5, 7, 9, and 11 years. We used linear mixed-effects models to assess associations of mtDNAcn tertiles in cord blood with child BMI, BMI z scores, fat mass index, and body fat percentage. Latent class growth models and interactions between mtDNAcn and child age or child age

resultsBMI was, on average, 1.5 kg/m

conclusionsLower mtDNAcn at birth may predict greater childhood adiposity, highlighting the potential key role of perinatal mitochondrial function in adiposity during development.

Indexed as

AdiposityBody Mass IndexDNA Copy Number VariationsDNA, MitochondrialFetal BloodPediatric ObesityBirth CohortBlack or African AmericanChildChild, PreschoolDominican RepublicFemaleHumansMaleNew York CityProspective StudiesDNA, Mitochondrial

Identifiers

PMID38454311
PMCPMC11817725
OpenAlexW4392592791

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.