Evidence map›Paper›PMID 38454122›Full record

ArticleScientific reports2024

Synthesis, anticancer activity, and molecular docking of half-sandwich iron(II) cyclopentadienyl complexes with maleimide and phosphine or phosphite ligands.

Sujoy Das, Marcelina Strachanowska, Piotr Wadowski, Michał Juszczak, Paulina Tokarz, Aneta Kosińska, Marcin Palusiak, Agnieszka J Rybarczyk-Pirek, Kinga Wzgarda-Raj, Saranya Vasudevan and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Sujoy DasDepartment of Organic Chemistry, University of Lodz, Faculty of Chemistry, Tamka 12, 91-403, Lodz, Poland.
Marcelina StrachanowskaDepartment of Molecular Genetics, University of Lodz, Faculty of Biology and Environmental Protection, Pomorska 141/143, 90-236, Lodz, Poland.
Piotr WadowskiDepartment of Molecular Genetics, University of Lodz, Faculty of Biology and Environmental Protection, Pomorska 141/143, 90-236, Lodz, Poland.
Michał JuszczakDepartment of Molecular Genetics, University of Lodz, Faculty of Biology and Environmental Protection, Pomorska 141/143, 90-236, Lodz, Poland.
Paulina TokarzDepartment of Molecular Genetics, University of Lodz, Faculty of Biology and Environmental Protection, Pomorska 141/143, 90-236, Lodz, Poland.
Aneta KosińskaDepartment of Organic Chemistry, University of Lodz, Faculty of Chemistry, Tamka 12, 91-403, Lodz, Poland.
Marcin PalusiakDepartment of Physical Chemistry, University of Lodz, Faculty of Chemistry, Pomorska 163/165, 90-236, Lodz, Poland.
Agnieszka J Rybarczyk-PirekDepartment of Physical Chemistry, University of Lodz, Faculty of Chemistry, Pomorska 163/165, 90-236, Lodz, Poland.
Kinga Wzgarda-RajDepartment of Physical Chemistry, University of Lodz, Faculty of Chemistry, Pomorska 163/165, 90-236, Lodz, Poland.
Saranya VasudevanCentre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363, Lodz, Poland.
Arkadiusz ChworosCentre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363, Lodz, Poland.
Katarzyna WoźniakDepartment of Molecular Genetics, University of Lodz, Faculty of Biology and Environmental Protection, Pomorska 141/143, 90-236, Lodz, Poland. katarzyna.wozniak@biol.uni.lodz.pl.
Bogna RudolfDepartment of Organic Chemistry, University of Lodz, Faculty of Chemistry, Tamka 12, 91-403, Lodz, Poland. bogna.rudolf@chemia.uni.lodz.pl.
University of Łódź · PLPolish Academy of Sciences · PL

Funding

Interdisciplinary Research Grant of the University of Lodz IDUB B2311013000182.07
6 · The paper itself

Abstract

In these studies, we designed and investigated the potential anticancer activity of five iron(II) cyclopentadienyl complexes bearing different phosphine and phosphite ligands. All complexes were characterized with spectroscopic analysis viz. NMR, FT-IR, ESI-MS, UV-Vis, fluorescence, XRD (for four complexes) and elemental analyses. For biological studies, we used three types of cells-normal peripheral blood mononuclear (PBM) cells, leukemic HL-60 cells and non-small-cell lung cancer A549 cells. We evaluated cell viability and DNA damage after cell incubation with these complexes. We observed that all iron(II) complexes were more cytotoxic for HL-60 cells than for A549 cells. The complex CpFe(CO)(P(OPh)

Indexed as

Antineoplastic AgentsCarcinoma, Non-Small-Cell LungCoordination ComplexesLung NeoplasmsPhosphinesPhosphitesCell Line, TumorDNAFerrous CompoundsHumansIronLeukocytes, MononuclearLigandsMaleimidesMolecular Docking SimulationSpectroscopy, Fourier Transform InfraredAntineoplastic AgentsCoordination ComplexesDNAFerrous CompoundsIronLigandsMaleimidesphosphinePhosphinesPhosphites

Identifiers

PMID38454122
PMCPMC10920834
OpenAlexW4392549821

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.