Evidence map›Paper›PMID 38454000›Full record

ArticleNature communications2024

Control of feeding by a bottom-up midbrain-subthalamic pathway.

Fernando M C V Reis, Sandra Maesta-Pereira, Matthias Ollivier, Peter J Schuette, Ekayana Sethi, Blake A Miranda, Emily Iniguez, Meghmik Chakerian, Eric Vaughn, Megha Sehgal and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Targeted Mechanogenetics to Modulate Specific Deep Neural Circuits.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Pregnancy damps thermoregulatory rhythms across timescales through neural estrogen signaling in mice.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Hypothalamic Control of Learned Flight Induced by Threat Imminence.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  7. The ARCNature communications · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 2 countries.

Fernando M C V ReisDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, 90095, USA. freis@ucla.edu.
Sandra Maesta-PereiraDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.ORCID 0000-0001-6522-8311
Matthias OllivierDepartment of Physiology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Peter J SchuetteDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Ekayana SethiDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Blake A MirandaDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Emily IniguezDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Meghmik ChakerianDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Eric VaughnDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA, 02138, USA.
Megha SehgalDepartment of Neurobiology, University of California, Los Angeles, Los Angeles, USA.
Darren C T NguyenDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Faith T H YuanDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Anita TorossianDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Juliane M IkebaraCentro de Matemática, Computação e Cognição, Universidade Federal do ABC, São Bernardo do Campo, SP, 09606-070, Brazil.
Alexandre H KiharaCentro de Matemática, Computação e Cognição, Universidade Federal do ABC, São Bernardo do Campo, SP, 09606-070, Brazil.ORCID 0000-0002-4027-7261
Alcino J SilvaDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Jonathan C KaoDepartment of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Baljit S KhakhDepartment of Physiology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.ORCID 0000-0002-0939-1218
Avishek AdhikariDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, 90095, USA. avi@psych.ucla.edu.ORCID 0000-0002-9187-9211
University of California, Los Angeles · USUniversidade Federal do ABC · BRHarvard University · US

Funding

Dissection of Hypothalamic-Brainstem Circuits in Panic-Related Escape BehaviorR01MH119089 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ADHIKARI, AVISHEK · 2019 to 2023
$2.1M
GABAergic Cells in the Periaqueductal Gray Region Control Food-SeekingR01DK139605 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Avishek Adhikari · 2024 to 2026
$1.6M
Dissection of the anxiety suppression circuitryR00MH106649 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ADHIKARI, AVISHEK · 2017 to 2019
$747k
Dissecting Cell-Specific Brainstem Circuits Mediating Escape BehaviorF31MH127943 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TOROSSIAN, ANITA · 2022 to 2024
$119k
NIDDK NIH HHS R01 DK139605NIMH NIH HHS F31 MH127943NIMH NIH HHS R00 MH106649NIMH NIH HHS R01 MH119089
6 · The paper itself

Abstract

Investigative exploration and foraging leading to food consumption have vital importance, but are not well-understood. Since GABAergic inputs to the lateral and ventrolateral periaqueductal gray (l/vlPAG) control such behaviors, we dissected the role of vgat-expressing GABAergic l/vlPAG cells in exploration, foraging and hunting. Here, we show that in mice vgat l/vlPAG cells encode approach to food and consumption of both live prey and non-prey foods. The activity of these cells is necessary and sufficient for inducing food-seeking leading to subsequent consumption. Activation of vgat l/vlPAG cells produces exploratory foraging and compulsive eating without altering defensive behaviors. Moreover, l/vlPAG vgat cells are bidirectionally interconnected to several feeding, exploration and investigation nodes, including the zona incerta. Remarkably, the vgat l/vlPAG projection to the zona incerta bidirectionally controls approach towards food leading to consumption. These data indicate the PAG is not only a final downstream target of top-down exploration and foraging-related inputs, but that it also influences these behaviors through a bottom-up pathway.

Indexed as

Periaqueductal GrayAnimalsMice

Identifiers

PMID38454000
PMCPMC10920831
OpenAlexW4392542859

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.