Evidence map›Paper›PMID 38453923›Full record

ArticleNature communications2024

Bioengineered amyloid peptide for rapid screening of inhibitors against main protease of SARS-CoV-2.

Dongtak Lee, Hyo Gi Jung, Dongsung Park, Junho Bang, Da Yeon Cheong, Jae Won Jang, Yonghwan Kim, Seungmin Lee, Sang Won Lee, Gyudo Lee and 5 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Uncovering the covalent inhibitors of SARS-CoV-2 MJournal of pharmaceutical analysis · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 4 countries.

Dongtak Lee *School of Biomedical Engineering, Korea University, Seoul, 02841, South Korea.ORCID 0000-0001-8716-1736
Hyo Gi Jung *School of Biomedical Engineering, Korea University, Seoul, 02841, South Korea.
Dongsung Park *School of Biomedical Engineering, Korea University, Seoul, 02841, South Korea.ORCID 0000-0001-5235-7114
Junho BangSchool of Biomedical Engineering, Korea University, Seoul, 02841, South Korea.
Da Yeon CheongDepartment of Biotechnology and Bioinformatics, Korea University, Sejong, 30019, South Korea.
Jae Won JangSchool of Biomedical Engineering, Korea University, Seoul, 02841, South Korea.
Yonghwan KimSchool of Biomedical Engineering, Korea University, Seoul, 02841, South Korea.
Seungmin LeeSchool of Biomedical Engineering, Korea University, Seoul, 02841, South Korea.
Sang Won LeeSchool of Biomedical Engineering, Korea University, Seoul, 02841, South Korea.
Gyudo LeeDepartment of Biotechnology and Bioinformatics, Korea University, Sejong, 30019, South Korea.
Yeon Ho KimSchool of Biomedical Engineering, Korea University, Seoul, 02841, South Korea.
Ji Hye HongSchool of Biomedical Engineering, Korea University, Seoul, 02841, South Korea.
Kyo Seon HwangDepartment of Clinical Pharmacology and Therapeutics, College of Medicine, Kyung Hee University, Seoul, 02447, South Korea. k.hwang@khu.ac.kr.ORCID 0000-0003-3590-2074
Jeong Hoon LeeDepartment of Electrical Engineering, Kwangwoon University, Seoul, 01897, South Korea. jhlee@kw.ac.kr.ORCID 0000-0001-7344-6060
Dae Sung YoonSchool of Biomedical Engineering, Korea University, Seoul, 02841, South Korea. dsyoon@korea.ac.kr.ORCID 0000-0002-6447-2862
Korea University · KRKwangwoon University · KRBrigham and Women's Hospital · USKyung Hee University · KR

Funding

Korea Health Industry Development Institute (KHIDI) HU21C0053National Research Foundation of Korea (NRF) NRF-2020R1A2C2102262National Research Foundation of Korea (NRF) NRF-2021R1A2C2004760National Research Foundation of Korea (NRF) NRF-2022R1A6A3A03066467
6 · The paper itself

Abstract

The coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has evoked a worldwide pandemic. As the emergence of variants has hampered the neutralization capacity of currently available vaccines, developing effective antiviral therapeutics against SARS-CoV-2 and its variants becomes a significant challenge. The main protease (M

Indexed as

COVID-19Metal NanoparticlesAntiviral AgentsGoldHumansMolecular Docking SimulationPeptide HydrolasesPeptidesProtease InhibitorsSARS-CoV-2Viral Nonstructural ProteinsAntiviral AgentsGoldPeptide HydrolasesPeptidesProtease InhibitorsViral Nonstructural Proteins

Identifiers

PMID38453923
PMCPMC10920794
OpenAlexW4392543335

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.