Evidence map›Paper›PMID 38453887›Full record

ArticleNature communications2024

Epigenetic profiling reveals key genes and cis-regulatory networks specific to human parathyroids.

Youngsook Lucy Jung, Wenping Zhao, Ian Li, Dhawal Jain, Charles B Epstein, Bradley E Bernstein, Sareh Parangi, Richard Sherwood, Cassianne Robinson-Cohen, Yi-Hsiang Hsu and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
3.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Youngsook Lucy JungDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA. Youngsook_Jung@hms.harvard.edu.ORCID 0000-0002-4736-6961
Wenping ZhaoEndocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Ian LiEndocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-2047-3027
Dhawal JainDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Charles B EpsteinBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0001-8358-8345
Bradley E BernsteinBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-5726-6278
Sareh ParangiDepartment of Surgery, Newton Wellesley Hospital and Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Richard SherwoodDivision of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Cambridge, MA, USA.ORCID 0000-0001-7427-7713
Cassianne Robinson-CohenDivision of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Yi-Hsiang HsuHinda and Arthur Marcus Institute for Aging Research, Hebrew Senior Life, Boston, MA, USA.
Peter J ParkDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-9378-960X
Michael MannstadtEndocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. mannstadt@mgh.harvard.edu.ORCID 0000-0003-0867-9778
Harvard University · USBroad Institute · USBeth Israel Deaconess Medical Center · USBoston Children's Hospital · USBrigham and Women's Hospital · USVanderbilt University Medical Center · US

Funding

Expanding the catalog of chromatin regulatory elements in the human genomeU54HG006991 · NHGRI · BROAD INSTITUTE, INC. · PI BERNSTEIN, BRADLEY EVAN · 2012 to 2016
$7.9M
Mode of Action of GCM2, the Essential Parathyroid Transcription FactorR01DK100584 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MANNSTADT, MICHAEL · 2014 to 2018
$1.8M
NHGRI NIH HHS U54 HG006991NIDDK NIH HHS R01 DK100584
6 · The paper itself

Abstract

In all terrestrial vertebrates, the parathyroid glands are critical regulators of calcium homeostasis and the sole source of parathyroid hormone (PTH). Hyperparathyroidism and hypoparathyroidism are clinically important disorders affecting multiple organs. However, our knowledge regarding regulatory mechanisms governing the parathyroids has remained limited. Here, we present the comprehensive maps of the chromatin landscape of the human parathyroid glands, identifying active regulatory elements and chromatin interactions. These data allow us to define regulatory circuits and previously unidentified genes that play crucial roles in parathyroid biology. We experimentally validate candidate parathyroid-specific enhancers and demonstrate their integration with GWAS SNPs for parathyroid-related diseases and traits. For instance, we observe reduced activity of a parathyroid-specific enhancer of the Calcium Sensing Receptor gene, which contains a risk allele associated with higher PTH levels compared to the wildtype allele. Our datasets provide a valuable resource for unraveling the mechanisms governing parathyroid gland regulation in health and disease.

Indexed as

CalciumParathyroid GlandsAnimalsChromatinEpigenesis, GeneticHumansParathyroid HormoneCalciumChromatinParathyroid Hormone

Identifiers

PMID38453887
PMCPMC10920874
OpenAlexW4392544443

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.