Evidence map›Paper›PMID 38453773›Full record

ArticleReproductive sciences (Thousand Oaks, Calif.)2024

Mechanism Research of DHEA Treatment Improving Diminished Ovarian Reserve by Attenuating the AMPK-SIRT1 Signaling and Mitophagy.

Qianwen Ma, Mingxia Shen, Jianfei Wu, Chenshu Ye, Yong Tan

Abstract read
PubMed Publisher
In one paragraph

Article in Reproductive sciences (Thousand Oaks, Calif.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  12. Potential Ameliorative Effect ofIranian journal of pharmaceutical research : IJPR
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Qianwen MaTCM Department, Hangzhou Ninth People's Hospital, Number 98, Yilong Road, Yipeng Street, Qiantang District, Hangzhou, 311225, Zhejiang, China. 185849087@qq.com.ORCID 0000-0003-2419-2951
Mingxia ShenTCM Department, Hangzhou Ninth People's Hospital, Number 98, Yilong Road, Yipeng Street, Qiantang District, Hangzhou, 311225, Zhejiang, China.
Jianfei WuTCM Department, Hangzhou Ninth People's Hospital, Number 98, Yilong Road, Yipeng Street, Qiantang District, Hangzhou, 311225, Zhejiang, China.
Chenshu YeTCM Department, Hangzhou Ninth People's Hospital, Number 98, Yilong Road, Yipeng Street, Qiantang District, Hangzhou, 311225, Zhejiang, China.
Yong TanReproductive Medicine Department, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.

Funding

Open project of Zhenjiang Clinical Medical Research Center for gynecological diseases of traditional Chinese medicine SS202204-KFB01Zhejiang Provincial Natural Science Foundation LQ23H270018Zhejiang Technology Program Project of Medicine and Health Science 2023RC071Zhejiang Technology Program Project of Traditional Chinese Medicine 2023ZL127Zhenjiang Social Development of Key Research Project SH2021025
6 · The paper itself

Abstract

This study aims to investigate the effect and mechanism of dehydroepiandrosterone (DHEA) on diminished ovarian reserve (DOR) by modulating the AMPK-SIRT1 signaling and mitophagy in rats. Three-month-old female Sprague-Dawley (SD) rats were randomized and injected intraperitoneally with sesame oil as the control or deoxyvinylcyclohexene (VCD) to induce DOR. The VCD-injected rats were randomized and injected subcutaneously with vehicle as the model group or with DHEA for 21 days as the DHEA group. After being identified in proestrus, rat blood samples were collected to prepare serum samples, and their ovarian tissues were dissected. Compared with the controls, significantly lower serum estradiol (E

Indexed as

AMP-Activated Protein KinasesDehydroepiandrosteroneMitophagyOvarian ReserveRats, Sprague-DawleySignal TransductionSirtuin 1AnimalsFemaleOvaryRatsAMP-Activated Protein KinasesDehydroepiandrosteroneSirt1 protein, ratSirtuin 1AMPK-SIRT1 signaling pathwayDHEADiminished ovarian reserveMitophagyOvary

Identifiers

PMID38453773

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.