Evidence map›Paper›PMID 38453713›Full record

Observational studyEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2024

Leishmaniasis in otorhinolaryngology: an emerging disease and its relationship with anti-tumor necrosis factor-alpha drugs.

Anna Penella, Clara Muntaner-Virgili, Joaquim Marcoval, Xavier González-Compta, Marta Mesalles-Ruiz, Miguel García Wagner, Francesc Cruellas, Miriam Hamdan, Julio Nogués, Jaime Notario

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Mucosal leishmaniasis of the nasal septum: diagnostic pitfalls and management considerations.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anna PenellaOtorhinolaryngology Department, Hospital Universitari de Bellvitge, Universitat de Barcelona (UB), IDIBELL, Feixa Llarga, s/n, 08907, L'Hospitalet de Llobregat, Spain. apenella@bellvitgehospital.cat.ORCID http://orcid.org/0000-0003-0100-4807
Clara Muntaner-VirgiliDermatology Department, Hospital Universitari de Bellvitge, Universitat de Barcelona (UB), IDIBELL, Feixa Llarga, s/n, 08907, L'Hospitalet de Llobregat, Spain.
Joaquim MarcovalDermatology Department, Hospital Universitari de Bellvitge, Universitat de Barcelona (UB), IDIBELL, Feixa Llarga, s/n, 08907, L'Hospitalet de Llobregat, Spain.
Xavier González-ComptaOtorhinolaryngology Department, Hospital Universitari de Bellvitge, Universitat de Barcelona (UB), IDIBELL, Feixa Llarga, s/n, 08907, L'Hospitalet de Llobregat, Spain.
Marta Mesalles-RuizOtorhinolaryngology Department, Hospital Universitari de Bellvitge, Universitat de Barcelona (UB), IDIBELL, Feixa Llarga, s/n, 08907, L'Hospitalet de Llobregat, Spain.
Miguel García WagnerOtorhinolaryngology Department, Hospital Universitari de Bellvitge, Universitat de Barcelona (UB), IDIBELL, Feixa Llarga, s/n, 08907, L'Hospitalet de Llobregat, Spain.
Francesc CruellasOtorhinolaryngology Department, Hospital Universitari de Bellvitge, Universitat de Barcelona (UB), IDIBELL, Feixa Llarga, s/n, 08907, L'Hospitalet de Llobregat, Spain.
Miriam HamdanOtorhinolaryngology Department, Hospital Universitari de Bellvitge, Universitat de Barcelona (UB), IDIBELL, Feixa Llarga, s/n, 08907, L'Hospitalet de Llobregat, Spain.
Julio NoguésOtorhinolaryngology Department, Hospital Universitari de Bellvitge, Universitat de Barcelona (UB), IDIBELL, Feixa Llarga, s/n, 08907, L'Hospitalet de Llobregat, Spain.
Jaime NotarioDermatology Department, Hospital Universitari de Bellvitge, Universitat de Barcelona (UB), IDIBELL, Feixa Llarga, s/n, 08907, L'Hospitalet de Llobregat, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the clinical manifestations, management and outcomes of Leishmania lesions in the ear-nose-throat (ENT) region, and its relationship with tumor necrosis factor (TNF)-α blocking drugs.

methodsSingle-center retrospective observational study. Patients diagnosed with cutaneous and mucosal leishmaniasis in the otorhinolaryngologic area at a tertiary referral center over a period of 8 years.

resultsThree cases of Leishmania lesions in the ear and two in the nose were encountered at our institution. All patients were under treatment with TNF-α blocking drugs. Diagnosis was challenging, and it was important to have a clinical suspicion in order to use accurate detection techniques. All patients received systemic treatment and achieved a complete resolution of the lesions.

conclusionsWith the increasing use of biologic treatments like TNF-α blockers, this type of infection will be increasingly frequent in endemic areas and also worldwide. It is important to include leishmaniasis in the differential diagnosis of inflammatory/infectious lesions in the ENT region.

Indexed as

LeishmaniasisLeishmaniasis, CutaneousOtolaryngologyHumansRetrospective StudiesSkinTumor Necrosis Factor-alphaTumor Necrosis Factor-alphaAnti-TNF alphaEmerging diseaseLeishmaniaLeishmaniasisOtorhinolaryngology

Identifiers

PMID38453713

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.