Evidence map›Paper›PMID 38453481›Full record

ArticleGenes & development2024

A maternal-effect

Carlo Giaccari, Francesco Cecere, Lucia Argenziano, Angela Pagano, Antonio Galvao, Dario Acampora, Gianna Rossi, Bruno Hay Mele, Basilia Acurzio, Scott Coonrod and 6 more

Open access · diamondAbstract read
In one paragraph

Article in Genes & development, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
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  15. Germline variants inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  16. Article
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  18. Article
  19. Article
  20. The Mammalian Oocyte: A Central Hub for Cellular Reprogramming and Stemness.Stem cells and cloning : advances and applications · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 4 countries.

Carlo GiaccariDepartment of Environmental Biological and Pharmaceutical Sciences and Technologies (DiSTABiF), Università degli Studi della Campania "Luigi Vanvitelli," Caserta 81100, Italy.
Francesco CecereDepartment of Environmental Biological and Pharmaceutical Sciences and Technologies (DiSTABiF), Università degli Studi della Campania "Luigi Vanvitelli," Caserta 81100, Italy.
Lucia ArgenzianoDepartment of Environmental Biological and Pharmaceutical Sciences and Technologies (DiSTABiF), Università degli Studi della Campania "Luigi Vanvitelli," Caserta 81100, Italy.
Angela PaganoDepartment of Environmental Biological and Pharmaceutical Sciences and Technologies (DiSTABiF), Università degli Studi della Campania "Luigi Vanvitelli," Caserta 81100, Italy.
Antonio GalvaoEpigenetics Programme, The Babraham Institute, Cambridge CB22 3AT, United Kingdom.
Dario AcamporaInstitute of Genetics and Biophysics (IGB) "Adriano Buzzati-Traverso," Consiglio Nazionale delle Ricerche (CNR), Naples 80131, Italy.
Gianna RossiDepartment of Life, Health, and Environmental Sciences, Università dell'Aquila, L'Aquila 67100, Italy.
Bruno Hay MeleDepartment of Biology, University of Naples "Federico II," Napoli 80126, Italy.ORCID 0000-0001-5579-183X
Basilia AcurzioDepartment of Environmental Biological and Pharmaceutical Sciences and Technologies (DiSTABiF), Università degli Studi della Campania "Luigi Vanvitelli," Caserta 81100, Italy.
Scott CoonrodBaker Institute for Animal Health, Cornell University, Ithaca, New York 14853, USA.
Maria Vittoria CubellisDepartment of Biology, University of Naples "Federico II," Napoli 80126, Italy.
Flavia CerratoDepartment of Environmental Biological and Pharmaceutical Sciences and Technologies (DiSTABiF), Università degli Studi della Campania "Luigi Vanvitelli," Caserta 81100, Italy.ORCID 0000-0003-3794-3021
Simon AndrewsBioinformatics Unit, The Babraham Institute, Cambridge CB22 3AT, United Kingdom.
Sandra CecconiDepartment of Life, Health, and Environmental Sciences, Università dell'Aquila, L'Aquila 67100, Italy.
Gavin KelseyEpigenetics Programme, The Babraham Institute, Cambridge CB22 3AT, United Kingdom; andrea.riccio@unicampania.it gavin.kelsey@babraham.ac.uk.ORCID 0000-0002-9762-5634
Andrea RiccioDepartment of Environmental Biological and Pharmaceutical Sciences and Technologies (DiSTABiF), Università degli Studi della Campania "Luigi Vanvitelli," Caserta 81100, Italy; andrea.riccio@unicampania.it gavin.kelsey@babraham.ac.uk.ORCID 0000-0001-7990-3576
University of Campania "Luigi Vanvitelli" · ITBabraham Institute · GBFederico II University Hospital · ITUniversity of L'Aquila · ITCornell University · USInstitute of Genetics and Biophysics · IT

Funding

Medical Research Council MR/K011332/1Medical Research Council MR/S000437/1Wellcome Trust 210754/Z/18/Z
6 · The paper itself

Abstract

Maternal inactivation of genes encoding components of the subcortical maternal complex (SCMC) and its associated member, PADI6, generally results in early embryo lethality. In humans, SCMC gene variants were found in the healthy mothers of children affected by multilocus imprinting disturbances (MLID). However, how the SCMC controls the DNA methylation required to regulate imprinting remains poorly defined. We generated a mouse line carrying a

Indexed as

OocytesZygoteAnimalsCCAAT-Enhancer-Binding ProteinsChildCytoplasmDNA MethylationEmbryonic DevelopmentFemaleGenomic ImprintingHumansMiceProtein-Arginine Deiminase Type 6Ubiquitin-Protein LigasesCCAAT-Enhancer-Binding ProteinsPADI6 protein, mouseProtein-Arginine Deiminase Type 6Ubiquitin-Protein LigasesUHRF1 protein, humanDNMT1 localizationepigenetic reprogrammingimprinting disordersmaternal-effect genesmultilocus imprinting disturbancePadi6subcortical maternal complexzygotic genome activation

Identifiers

PMID38453481
PMCPMC10982689
OpenAlexW4392564506

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.