Evidence map›Paper›PMID 38453257›Full record

ArticleThe European respiratory journal2024

Multi-biobank summary data Mendelian randomisation does not support a causal effect of IL-6 signalling on risk of pulmonary arterial hypertension.

Benjamin Woolf, James A Perry, Charles C Hong, Martin R Wilkins, Mark Toshner, Dipender Gill, Stephen Burgess, Christopher J Rhodes

Open access · hybridAbstract readLetter
In one paragraph

Article in The European respiratory journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Benjamin WoolfThe MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK benjamin.woolf@bristol.ac.uk.ORCID https://orcid.org/0000-0002-1505-2570
James A PerryDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Charles C HongDepartment of Medicine, Michigan State University College of Human Medicine, East Lansing, MI, USA.ORCID https://orcid.org/0000-0002-0424-8252
Martin R WilkinsNational Heart and Lung Institute, Imperial College London, London, UK.ORCID https://orcid.org/0000-0003-3926-1171
Mark ToshnerDepartment of Medicine, University of Cambridge, Cambridge, UK.ORCID https://orcid.org/0000-0002-3969-6143
Dipender GillDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Stephen BurgessThe MRC Biostatistics Unit, University of Cambridge, Cambridge, UK.
Christopher J RhodesNational Heart and Lung Institute, Imperial College London, London, UK.
Imperial College London · GBUniversity of Cambridge · GBMichigan State University · USUniversity of Maryland, Baltimore · US

Funding

British Heart Foundation FS/15/59/31839British Heart Foundation FS/SBSRF/22/31025Wellcome Trust 225790
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Interleukin-6Pulmonary Arterial HypertensionBiological Specimen BanksFamilial Primary Pulmonary HypertensionGenome-Wide Association StudyHumansPolymorphism, Single NucleotideRisk FactorsInterleukin-6

Identifiers

PMID38453257
PMCPMC10991834
OpenAlexW4392563079

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.