Evidence map›Paper›PMID 38453034›Full record

ArticleNeurotoxicology2024

Organophosphorus pesticide exposure from house dust and parent-reported child behavior in Latino children from an orchard community.

Khalid M Khan, Marie E Gaine, Alyssa R Daniel, Pavani Chilamkuri, Diane S Rohlman

Abstract read
In one paragraph

Article in Neurotoxicology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Khalid M KhanDepartment of Public Health, College of Health Sciences, Sam Houston State University, 1901 Ave I, Huntsville, TX 77340, USA. Electronic address: kxk051@shsu.edu.
Marie E GaineDepartment of Pharmaceutical Sciences and Experimental Therapeutics (PSET), College of Pharmacy, University of Iowa, 546 CPB, 180 S Grand Ave, Iowa City, IA 52242, USA; Interdisciplinary Graduate Program in Human Toxicology, University of Iowa, Iowa City, IA 52242, USA.
Alyssa R DanielDepartment of Pharmaceutical Sciences and Experimental Therapeutics (PSET), College of Pharmacy, University of Iowa, 546 CPB, 180 S Grand Ave, Iowa City, IA 52242, USA; Interdisciplinary Graduate Program in Human Toxicology, University of Iowa, Iowa City, IA 52242, USA.
Pavani ChilamkuriDepartment of Public Health, College of Health Sciences, Sam Houston State University, 1901 Ave I, Huntsville, TX 77340, USA.
Diane S RohlmanDepartment of Occupational and Environmental Health, College of Public Health, University of Iowa, S143 CPHB 145 N. Riverside Drive, Iowa City, IA 52242, USA.

Funding

Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5M
University of Iowa Hawkeye Intellectual and Developmental Disabilities Research Center (Hawk-IDDRC)P50HD103556 · NICHD · UNIVERSITY OF IOWA · PI EDWIN TED G. ABEL, Lane Strathearn · 2021 to 2026
$8.5M
Pacific Northwest Agricultural Safety and Health CenterU50OH007544 · OH · UNIVERSITY OF WASHINGTON · PI FENSKE, RICHARD ARNOLD · 2001 to 2010
$7.1M
NICHD NIH HHS P50 HD103556NIEHS NIH HHS P30 ES005605NIOSH CDC HHS U50 OH007544NIOSH CDC HHS U54 OH007544
6 · The paper itself

Abstract

backgroundOrganophosphorus pesticide (OP) exposure is known to have adverse effects on the nervous system. Children from agricultural communities are at risk of exposure to these chemicals from their indoor environments that can lead to neurological and developmental problems, including changes in behavior.

objectiveThe aim of this study is to evaluate whether the take-home pathway exposure is associated with behavioral and emotional problems in Latino Orchid Community children.

methodThe study was implemented over a period of two years (2008-2010) in an orchard farming community with a total of 324 parents who had children between the ages of 5-12 years old. Mothers of the children were asked to complete the Child Behavior Checklist (CBCL) and dust from their carpets was collected. Emotional and behavioral deficits were assessed based on the CBCL and house dust was assessed for OP concentrations. In this study, correlations between OPs in house dust and CBCL subscales were estimated using linear regression models with total OP concentrations classified by tertiles. This study also facilitated the comparison between the agricultural and non-agricultural families in terms of behavioral deficits and house dust concentrations of pesticides.

resultsThe data from the study shows that there was a positive association between the concentration of OP residues in house dust and internalizing behavior (β=2.06, p=0.05) whereas the association with externalizing behavior was not significant after accounting for sociocultural covariates. Significant positive associations of OP residues with somatic problems (p=0.02) and thought problems (p=0.05) were also found.

conclusionThe data support a potential role of OP exposure in childhood development, with a specific focus on internalizing behavior. Future work focused on longitudinal studies may uncover the long-term consequences of OP exposure and behavior.

Indexed as

Child BehaviorDustEnvironmental ExposureHispanic or LatinoOrganophosphorus CompoundsPesticidesAgricultureChildChild Behavior DisordersChild, PreschoolFemaleHumansMaleParentsDustOrganophosphorus CompoundsPesticidesAgricultural communitiesBehavioral deficitsChildrenOrganophosphorus pesticidesTake-home exposure pathways

Identifiers

PMID38453034
PMCPMC11684323

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.