Evidence map›Paper›PMID 38452918›Full record

ReviewAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2024

Enhancing Kidney Transplantation and the Role of Xenografts: Report of a Scientific Workshop Sponsored by the National Kidney Foundation.

Andrew B Adams, Emily A Blumberg, John S Gill, Eliezer Katz, Tatsuo Kawai, Jesse D Schold, Megan Sykes, Alfred Tector, David H Sachs

Open access · greenAbstract readReview
In one paragraph

Review in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 8 institutions in 2 countries.

Andrew B AdamsDepartment of Surgery, School of Medicine, University of Minnesota, Minneapolis, Minnesota.
Emily A BlumbergDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
John S GillDivision of Nephrology, University of British Columbia, British Columbia, Vancouver, Canada.
Eliezer KatzeGenesis Bio, Cambridge, Massachusetts.
Tatsuo KawaiMassachusetts General Hospital, Harvard University, Boston, Massachusetts; Center for Transplantation Sciences, Harvard University, Boston, Massachusetts.
Jesse D ScholdDepartment of Surgery and Epidemiology, Anschutz Medical Campus, University of Colorado, Aurora, Colorado.
Megan SykesDepartment of Medicine, Columbia Center for Translational Immunology, and Department of Medicine, Department of Microbiology and Immunology, and Department of Surgery; Columbia University, New York, New York.
Alfred TectorDeWitt Daughtry Family Department of Surgery, School of Medicine, University of Miami, Miami, Florida.
David H SachsMassachusetts General Hospital, Harvard University, Boston, Massachusetts; Medical School, Harvard University, Boston, Massachusetts; Columbia University Medical Center, New York, New York. Electronic address: dhs2142@cumc.columbia.edu.
Columbia University · USColumbia University Irving Medical Center · USMassachusetts General Hospital · USUniversity of British Columbia · CAUniversity of Colorado Anschutz Medical Campus · USUniversity of Miami · USUniversity of Minnesota · USUniversity of Pennsylvania · US

Funding

XENOGRAFT TOLERANCE THROUGH MIXED CHIMERISMP01AI045897 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Megan Sykes · 2000 to 2026
$71.9M
NIAID NIH HHS P01 AI045897
6 · The paper itself

Abstract

Chronic kidney disease affects an estimated 37 million people in the United States; of these,>800,000 have end-stage renal disease requiring chronic dialysis or a kidney transplant to survive. Despite efforts to increase the donor kidney supply, approximately 100,000 people are registered on the kidney transplant wait-list with no measurable decrease over the past 2 decades. The outcomes of kidney transplantation are significantly better than for chronic dialysis: kidney transplant recipients have lower rates of mortality and cardiovascular events and better quality of life, but wait-list time matters. Time on dialysis waiting for a deceased-donor kidney is a strong independent risk factor for outcomes after a kidney transplant. Deceased-donor recipients with wait-list times on dialysis of<6 months have graft survival rates equivalent to living-donor recipients with waitlist times on dialysis of>2 years. In 2021,>12,000 people had been on the kidney transplant waitlist for ≥5 years. As the gap between the demand for and availability of donor kidneys for allotransplantation continues to widen, alternative strategies are needed to provide a stable, sufficient, and timely supply. A strategy that is gaining momentum toward clinical application is pig-to-human kidney xenotransplantation. This report summarizes the proceedings of a meeting convened on April 11-12, 2022, by the National Kidney Foundation to review and assess the state of pig-to-human kidney xenotransplantation as a potential cure for end-stage renal disease.

Indexed as

Kidney Failure, ChronicKidney TransplantationAnimalsFoundationsGraft SurvivalHeterograftsHumansTransplantation, HeterologousUnited StatesWaiting ListsDonor kidneysend-stage kidney diseasexenotransplantation

Identifiers

PMID38452918
PMCPMC11558888
OpenAlexW4392455616

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.