ArticleCell reports methods2024
GAUSS-EM, guided accumulation of ultrathin serial sections with a static magnetic field for volume electron microscopy.
Article in Cell reports methods, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Protocol for DRIFT-EM: Direct wafer retrieval of ultrathin serial sections for volume electron microscopy.STAR protocols · 2026Article
- RAEM: random-access electron microscopy for revisitable 3D imaging.bioRxiv : the preprint server for biology · 2026Article
- DRIFT-EM enables direct wafer retrieval of ultrathin serial sections for large-volume electron microscopy.Cell reports methods · 2026Article
- Synaptic-resolution connectomics: towards large brains and connectomic screening.Nature reviews. Neuroscience · 2026Review
- Photoemission electron microscopy for connectomics.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- FAST-EM array tomography: a workflow for multibeam volume electron microscopy.Methods in microscopy · 2024Article
- Array tomography: trails to discovery.Methods in microscopy · 2024Article
- Quantitative evaluation of embedding resins for volume electron microscopy.Frontiers in neuroscience · 2024Article
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3 authors.
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Abstract
Serial sectioning electron microscopy (EM) of millimeter-scale three-dimensional (3D) anatomical volumes requires the collection of thousands of ultrathin sections. Here, we report a high-throughput automated approach, GAUSS-EM (guided accumulation of ultrathin serial sections-EM), utilizing a static magnetic field to collect and densely pack thousands of sections onto individual silicon wafers. The method is capable of sectioning hundreds of microns of tissue per day at section thicknesses down to 35 nm. Relative to other automated volume EM approaches, GAUSS-EM democratizes the ability to collect large 3D EM volumes because it is simple and inexpensive to implement. We present two exemplar EM volumes of a zebrafish eye and mouse olfactory bulb collected with the method.
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Registered trials
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