Evidence map›Paper›PMID 38452758›Full record

ArticleDevelopmental cell2024

Type I gamma phosphatidylinositol phosphate 5-kinase i5 controls cell sensitivity to interferon.

Chinmoy Ghosh, Ruchi Kakar, Rosalie G Hoyle, Zheng Liu, Chunqing Guo, Jiong Li, Xiang-Yang Wang, Yue Sun

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Chinmoy GhoshDepartment of Oral and Craniofacial Molecular Biology, Philips Institute for Oral Health Research, School of Dentistry, Virginia Commonwealth University, Richmond, VA 23298, USA.
Ruchi KakarDepartment of Oral and Craniofacial Molecular Biology, Philips Institute for Oral Health Research, School of Dentistry, Virginia Commonwealth University, Richmond, VA 23298, USA.
Rosalie G HoyleDepartment of Medicinal Chemistry, Institute for Structural Biology, Drug Discovery and Development, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA.
Zheng LiuDepartment of Human and Molecular Genetics, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA.
Chunqing GuoDepartment of Human and Molecular Genetics, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA.
Jiong LiDepartment of Medicinal Chemistry, Institute for Structural Biology, Drug Discovery and Development, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA; Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA.
Xiang-Yang WangDepartment of Human and Molecular Genetics, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA; Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA.
Yue SunDepartment of Oral and Craniofacial Molecular Biology, Philips Institute for Oral Health Research, School of Dentistry, Virginia Commonwealth University, Richmond, VA 23298, USA; Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA. Electronic address: ysun4@vcu.edu.
Virginia Commonwealth University · US

Funding

Metabolic reprograming of fatty acid beta-oxidation to improve cancer immunotherapyR01CA229812 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI FANG, XIANJUN, WANG, XIANG-YANG SHAWN · 2019 to 2023
$2.0M
PIPKIgammai5 in the Control of HNSCC ProgressionR01DE029496 · NIDCR · VIRGINIA COMMONWEALTH UNIVERSITY · PI SUN, YUE · 2020 to 2024
$1.8M
NCI NIH HHS R01 CA229812NIDCR NIH HHS R01 DE029496
6 · The paper itself

Abstract

The interferon signaling pathway is critical for host defense by serving diverse functions in both innate and adaptive immune responses. Here, we show that type I gamma phosphatidylinositol phosphate 5-kinase i5 (PIPKIγi5), an enzyme that synthesizes phosphatidylinositol-4,5-bisphosphate (PI4,5P

Indexed as

Interferon-gammaPhosphotransferases (Alcohol Group Acceptor)Signal TransductionAnimalsHEK293 CellsHumansMiceProtein BindingSTAT1 Transcription FactorSTAT2 Transcription FactorSTAT3 Transcription Factor1-phosphatidylinositol-4-phosphate 5-kinaseInterferon-gammaPhosphotransferases (Alcohol Group Acceptor)STAT1 protein, humanSTAT1 Transcription FactorSTAT2 Transcription FactorSTAT3 Transcription Factorantiviralimmune responseinterferon signalingphosphoinositidePI4,5P(2)PIPKIγi5STAT1

Identifiers

PMID38452758
PMCPMC11043016
OpenAlexW4392519435

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.