Evidence map›Paper›PMID 38452289›Full record

ArticleJournal of the American Medical Informatics Association : JAMIA2024

Why do users override alerts? Utilizing large language model to summarize comments and optimize clinical decision support.

Siru Liu, Allison B McCoy, Aileen P Wright, Scott D Nelson, Sean S Huang, Hasan B Ahmad, Sabrina E Carro, Jacob Franklin, James Brogan, Adam Wright

Abstract read
In one paragraph

Article in Journal of the American Medical Informatics Association : JAMIA, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Prompt Engineering in Clinical Practice: Tutorial for Clinicians.Journal of medical Internet research · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Using large language model to guide patients to create efficient and comprehensive clinical care message.Journal of the American Medical Informatics Association : JAMIA · 2024
    Article
  15. Review
  16. What can you do with a large language model?Journal of the American Medical Informatics Association : JAMIA · 2024
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Siru LiuDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN 37212, United States.
Allison B McCoyDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN 37212, United States.ORCID 0000-0003-2292-9147
Aileen P WrightDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN 37212, United States.
Scott D NelsonDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN 37212, United States.ORCID 0000-0002-1941-1817
Sean S HuangDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN 37212, United States.
Hasan B AhmadDepartment of Biomedical Informatics and Medical Education, University of Washington, Seattle, WA 98195, United States.
Sabrina E CarroDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37212, United States.
Jacob FranklinDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN 37212, United States.
James BroganDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN 37212, United States.
Adam WrightDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN 37212, United States.ORCID 0000-0001-6844-145X

Funding

Safety Promotion through Early Event Detection in the Elderly (SPEEDe)R01AG062499 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WRIGHT, ADAM T · 2019 to 2023
$3.5M
Strategies for Engineering Reliable Value Sets (SERVS)R01LM013995 · NLM · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ADAM T WRIGHT · 2022 to 2026
$1.0M
Optimizing Clinical Decision Support Alerts Using Explainable Artificial Intelligence (XAI)R00LM014097 · NLM · VANDERBILT UNIVERSITY MEDICAL CENTER · PI LIU, SIRU · 2023 to 2024
$498k
NIA NIH HHS R01 AG062499NIH HHS R00LM014097-02NLM NIH HHS R00 LM014097NLM NIH HHS R01 LM013995
6 · The paper itself

Abstract

objectivesTo evaluate the capability of using generative artificial intelligence (AI) in summarizing alert comments and to determine if the AI-generated summary could be used to improve clinical decision support (CDS) alerts. MATERIALS AND

methodsWe extracted user comments to alerts generated from September 1, 2022 to September 1, 2023 at Vanderbilt University Medical Center. For a subset of 8 alerts, comment summaries were generated independently by 2 physicians and then separately by GPT-4. We surveyed 5 CDS experts to rate the human-generated and AI-generated summaries on a scale from 1 (strongly disagree) to 5 (strongly agree) for the 4 metrics: clarity, completeness, accuracy, and usefulness.

resultsFive CDS experts participated in the survey. A total of 16 human-generated summaries and 8 AI-generated summaries were assessed. Among the top 8 rated summaries, five were generated by GPT-4. AI-generated summaries demonstrated high levels of clarity, accuracy, and usefulness, similar to the human-generated summaries. Moreover, AI-generated summaries exhibited significantly higher completeness and usefulness compared to the human-generated summaries (AI: 3.4 ± 1.2, human: 2.7 ± 1.2, P = .001).

conclusionEnd-user comments provide clinicians' immediate feedback to CDS alerts and can serve as a direct and valuable data resource for improving CDS delivery. Traditionally, these comments may not be considered in the CDS review process due to their unstructured nature, large volume, and the presence of redundant or irrelevant content. Our study demonstrates that GPT-4 is capable of distilling these comments into summaries characterized by high clarity, accuracy, and completeness. AI-generated summaries are equivalent and potentially better than human-generated summaries. These AI-generated summaries could provide CDS experts with a novel means of reviewing user comments to rapidly optimize CDS alerts both online and offline.

Indexed as

Artificial IntelligenceDecision Support Systems, ClinicalMedical Order Entry SystemsElectronic Health RecordsHumansNatural Language Processingalert fatigueclinical decision supporthealth personnellarge language model

Identifiers

PMID38452289
PMCPMC11105133

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.