Evidence map›Paper›PMID 38452063›Full record

ArticleScience (New York, N.Y.)2024

Bioresorbable shape-adaptive structures for ultrasonic monitoring of deep-tissue homeostasis.

Jiaqi Liu, Naijia Liu, Yameng Xu, Mingzheng Wu, Haohui Zhang, Yue Wang, Ying Yan, Angela Hill, Ruihao Song, Zijie Xu and 16 more

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

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  18. Physical Intelligence in Small-Scale Robots and Machines.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

26 authors.

Jiaqi Liu *Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-5587-7243
Naijia Liu *Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0003-4705-2927
Yameng Xu *The Institute of Materials Science and Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA.
Mingzheng Wu *Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0003-4415-6296
Haohui Zhang *Department of Civil and Environmental Engineering, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0001-8432-3672
Yue WangQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-9763-3570
Ying YanDepartment of Neurosurgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
Angela HillDepartment of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
Ruihao SongQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.
Zijie XuQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.
Minsu ParkDepartment of Polymer Science and Engineering, Dankook University, Yongin 16890, Republic of Korea.ORCID 0000-0003-0759-8888
Yunyun WuQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.
Joanna L CiattiQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0001-5393-522X
Jianyu GuQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.
Haiwen LuanQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0003-0722-1108
Yamin ZhangQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0003-4890-1265
Tianyu YangQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.
Hak-Young AhnQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-5441-1054
Shupeng LiDepartment of Mechanical Engineering, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-8723-9369
Wilson Z RayDepartment of Neurosurgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
Colin K FranzRegenerative Neurorehabilitation Laboratory, Shirley Ryan AbilityLab, Chicago, IL 60611, USA.ORCID 0000-0003-4546-8638
Matthew R MacEwanDepartment of Neurosurgery, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-7911-3408
Yonggang HuangQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-0483-8359
Chet W HammillDepartment of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0001-9749-0824
Heling WangLaboratory of Flexible Electronics Technology, Tsinghua University, Beijing 100084, China.ORCID 0000-0001-7859-5153
John A RogersQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-3830-5980

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LEONIDAS C. PLATANIAS · 1993 to 2026
$153.9M
SURGICAL ONCOLOGY TRAINING GRANTT32CA009621 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN, William E. Gillanders · 1988 to 2026
$12.9M
NCI NIH HHS P30 CA060553NCI NIH HHS T32 CA009621
6 · The paper itself

Abstract

Monitoring homeostasis is an essential aspect of obtaining pathophysiological insights for treating patients. Accurate, timely assessments of homeostatic dysregulation in deep tissues typically require expensive imaging techniques or invasive biopsies. We introduce a bioresorbable shape-adaptive materials structure that enables real-time monitoring of deep-tissue homeostasis using conventional ultrasound instruments. Collections of small bioresorbable metal disks distributed within thin, pH-responsive hydrogels, deployed by surgical implantation or syringe injection, allow ultrasound-based measurements of spatiotemporal changes in pH for early assessments of anastomotic leaks after gastrointestinal surgeries, and their bioresorption after a recovery period eliminates the need for surgical extraction. Demonstrations in small and large animal models illustrate capabilities in monitoring leakage from the small intestine, the stomach, and the pancreas.

Indexed as

Absorbable ImplantsAnastomotic LeakGastrointestinal TractUltrasonicsAnimalsHomeostasisHumansModels, AnimalStomach

Identifiers

PMID38452063
PMCPMC13320384

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.