Evidence map›Paper›PMID 38451943›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

tRNA epitranscriptome determines pathogenicity of the opportunistic pathogen

Jonas Krueger, Matthias Preusse, Nicolas Oswaldo Gomez, Yannick Noah Frommeyer, Sebastian Doberenz, Anne Lorenz, Adrian Kordes, Svenja Grobe, Mathias Müsken, Daniel P Depledge and 7 more

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 27 citations in OpenAlex.

  1. Compendium of RNA modifications for bacterial stress adaptation.Microbiology and molecular biology reviews : MMBR · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. EnterohemorrhagicmSystems · 2026
    Article
  7. Article
  8. Antimicrobial agents and chemotherapy · 2026
    Article
  9. Article
  10. Article
  11. Pseudopaline-mediated zinc uptake byInfection and immunity · 2026
    Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. RNA modification is the mark and strategy for host-microbe interactions.Cellular and molecular life sciences : CMLS · 2025
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 2 countries.

Jonas Krueger *Institute for Molecular Bacteriology, Center of Clinical and Experimental Infection Research (TWINCORE), a joint venture of the Hannover Medical School and the Helmholtz Center for Infection Research, Hannover 30625, Germany.
Matthias Preusse *Department of Molecular Bacteriology, Helmholtz Center for Infection Research, 38124 Braunschweig, Germany.ORCID 0000-0002-2775-3139
Nicolas Oswaldo Gomez *Department of Molecular Bacteriology, Helmholtz Center for Infection Research, 38124 Braunschweig, Germany.ORCID 0000-0001-5723-886X
Yannick Noah FrommeyerInstitute for Molecular Bacteriology, Center of Clinical and Experimental Infection Research (TWINCORE), a joint venture of the Hannover Medical School and the Helmholtz Center for Infection Research, Hannover 30625, Germany.ORCID 0009-0001-2485-3724
Sebastian DoberenzInstitute for Molecular Bacteriology, Center of Clinical and Experimental Infection Research (TWINCORE), a joint venture of the Hannover Medical School and the Helmholtz Center for Infection Research, Hannover 30625, Germany.ORCID 0009-0000-1616-7540
Anne LorenzInstitute for Molecular Bacteriology, Center of Clinical and Experimental Infection Research (TWINCORE), a joint venture of the Hannover Medical School and the Helmholtz Center for Infection Research, Hannover 30625, Germany.
Adrian KordesInstitute for Molecular Bacteriology, Center of Clinical and Experimental Infection Research (TWINCORE), a joint venture of the Hannover Medical School and the Helmholtz Center for Infection Research, Hannover 30625, Germany.
Svenja GrobeInstitute for Molecular Bacteriology, Center of Clinical and Experimental Infection Research (TWINCORE), a joint venture of the Hannover Medical School and the Helmholtz Center for Infection Research, Hannover 30625, Germany.
Mathias MüskenCentral Facility for Microscopy, Helmholtz Centre for Infection Research, Braunschweig 38124, Germany.ORCID 0000-0002-5624-1378
Daniel P DepledgeCluster of Excellence "Resolving Infection susceptibility" (RESIST), Hannover Medical School, Hannover 30625, Germany.ORCID 0000-0002-4292-0599
Sarah L SvenssonDepartment of Molecular Infection Biology II, Institute of Molecular Infection Biology, University of Würzburg, Würzburg 97080, Germany.
Siegfried WeissInstitute of Immunology, Medical School Hannover, Hannover 30625, Germany.
Volkhard KaeverResearch Core Unit Metabolomics and Institute of Pharmacology, Hannover Medical School, Hannover 30625, Germany.
Andreas PichResearch Core Unit Proteomics and Institute for Toxicology, Hannover Medical School, Hannover 30625, Germany.
Cynthia M SharmaDepartment of Molecular Infection Biology II, Institute of Molecular Infection Biology, University of Würzburg, Würzburg 97080, Germany.ORCID 0000-0002-2321-9705
Zoya IgnatovaInstitute for Biochemistry and Molecular Biology, University Hamburg, 20146, Germany.ORCID 0000-0002-9478-8825
Susanne HäusslerInstitute for Molecular Bacteriology, Center of Clinical and Experimental Infection Research (TWINCORE), a joint venture of the Hannover Medical School and the Helmholtz Center for Infection Research, Hannover 30625, Germany.ORCID 0000-0001-6141-9102
Medizinische Hochschule Hannover · DEHelmholtz Centre for Infection Research · DEUniversity of Würzburg · DECopenhagen University Hospital · DK

Funding

Bayerisches Staatsministerium für Wirtschaft und Medien, Energie und Technologie (Bavarian Ministry of Economic Affairs and Media, Energy and Technology) grant allocation numbers 0703/68674/5/2017 and 0703/89374/3/2017Deutsche Forschungsgemeinschaft (DFG) DFG SPP 1879Deutsche Forschungsgemeinschaft (DFG) EXC 2155 "RESIST" Project ID 390874280Deutsche Forschungsgemeinschaft (DFG) grant Sh580/7-1 and 7.2 within the priority program SPP2002Deutsche Forschungsgemeinschaft (DFG) RA3259/2-1EC | ERC | HORIZON EUROPE European Research Council (ERC) COMBAT 724290Hamburg Innovation Grant C4T635Lower Saxony Ministry for Science and Culture BacData ZN3428Novo Nordisk Fonden (NNF) NNF 18OC0033946
6 · The paper itself

Abstract

The success of bacterial pathogens depends on the coordinated expression of virulence determinants. Regulatory circuits that drive pathogenesis are complex, multilayered, and incompletely understood. Here, we reveal that alterations in tRNA modifications define pathogenic phenotypes in the opportunistic pathogen

Indexed as

ProteomicsPseudomonas aeruginosaAnticodonBacteriaRNA, TransferVirulenceAnticodonRNA, TransferepitranscriptomicspathogenicityriboseqtranslationtRNA modification

Identifiers

PMID38451943
PMCPMC10945773
OpenAlexW4392564029

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.