Evidence map›Paper›PMID 38451498›Full record

ArticleJournal of the American Chemical Society2024

Force-Induced Site-Specific Enzymatic Cleavage Probes Reveal That Serial Mechanical Engagement Boosts T Cell Activation.

Jhordan Rogers, Rong Ma, Alexander Foote, Yuesong Hu, Khalid Salaita

Open access · hybridAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Detection of Mesenchymal Stem Cell Aging Using an Integrin Mechano-Probe.Annals of the New York Academy of Sciences · 2026
    Article
  3. Article
  4. Decoy DNA Protects Molecular Tension Probes from DNase Degradation.Angewandte Chemie (International ed. in English) · 2025
    Article
  5. Article
  6. Biphasic mechanochemistry of single-chain polymerization.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Review
  8. Review
  9. Editorial: Biomechanics in blood cell functions and diseases.Frontiers in bioengineering and biotechnology · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Jhordan RogersDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Rong MaDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Alexander FooteDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Yuesong HuDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Khalid SalaitaDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.ORCID 0000-0003-4138-3477
Emory University · USGeorgia Institute of Technology · US

Funding

Equipment Supplement: Cell sorting flow cytometry to support the BTDDRM1GM145394 · NIGMS · EMORY UNIVERSITY · PI Khalid S. Salaita · 2023 to 2026
$5.6M
Mechano-ID for tagging immune cellsR01AI172452 · NIAID · EMORY UNIVERSITY · PI Khalid S. Salaita · 2023 to 2026
$1.4M
Mechanical regulation of T cell receptor and co-receptor responses in cancer immunotherapyF99CA274690 · NCI · EMORY UNIVERSITY · PI HU, YUESONG · 2022 to 2023
$96k
NCI NIH HHS F99 CA274690NIAID NIH HHS R01 AI172452NIGMS NIH HHS RM1 GM145394
6 · The paper itself

Abstract

The T cell membrane is studded with >10

Indexed as

Mechanotransduction, CellularReceptors, Antigen, T-CellLymphocyte ActivationMechanical PhenomenaPeptidesProtein BindingT-LymphocytesPeptidesReceptors, Antigen, T-Cell

Identifiers

PMID38451498
PMCPMC10958510
OpenAlexW4392562765

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.