Evidence map›Paper›PMID 38451442›Full record

ReviewBiological trace element research2025

Immunomodulatory Effects of Vitamin D and Zinc on Viral Infection.

Muhammad Rizwan, Ke Cheng, Yang Gang, Yuntao Hou, Chunfang Wang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Biological trace element research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Vitamin DApplied microbiology and biotechnology · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Muhammad RizwanCollege of Fisheries, Huazhong Agriculture University, Wuhan, 430070, China.ORCID http://orcid.org/0000-0002-7419-0658
Ke ChengCollege of Fisheries, Huazhong Agriculture University, Wuhan, 430070, China.
Yang GangCollege of Fisheries, Huazhong Agriculture University, Wuhan, 430070, China.
Yuntao HouCollege of Fisheries, Huazhong Agriculture University, Wuhan, 430070, China.
Chunfang WangCollege of Fisheries, Huazhong Agriculture University, Wuhan, 430070, China. cfwang@mail.hzau.edu.cn.ORCID http://orcid.org/0000-0002-2016-864X
Huazhong Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several nutrients are crucial in enhancing the immune system and preserving the structural integrity of bodily tissue barriers. Vitamin D (VD) and zinc (Zn) have received considerable interest due to their immunomodulatory properties and ability to enhance the body's immune defenses. Due to their antiviral, anti-inflammatory, antioxidative, and immunomodulatory properties, the two nutritional powerhouses VD and Zn are crucial for innate and adaptive immunity. As observed with COVID-19, deficiencies in these micronutrients impair immune responses, increasing susceptibility to viral infections and severe disease. Ensuring an adequate intake of VD and Zn emerges as a promising strategy for fortifying the immune system. Ongoing clinical trials are actively investigating their potential therapeutic advantages. Beyond the immediate context of the pandemic, these micronutrients offer valuable tools for enhancing immunity and overall well-being, especially in the face of future viral threats. This analysis emphasizes the enduring significance of VD and Zn as both treatment and preventive measures against potential viral challenges beyond the current health crisis. The overview delves into the immunomodulatory potential of VD and Zn in combating viral infections, with particular attention to their effects on animals. It provides a comprehensive summary of current research findings regarding their individual and synergistic impacts on immune function, underlining their potential in treating and preventing viral infections. Overall, this overview underscores the need for further research to understand how VD and Zn can modulate the immune response in combatting viral diseases in animals.

Indexed as

COVID-19Virus DiseasesVitamin DZincAnimalsCOVID-19 Drug TreatmentHumansImmunologic FactorsImmunomodulating AgentsSARS-CoV-2Immunologic FactorsImmunomodulating AgentsVitamin DZincAdaptive immunityAntioxidantInfectionVitamin D

Identifiers

PMID38451442
OpenAlexW4392557425

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.