Evidence map›Paper›PMID 38451431›Full record

SynthesisInternational urology and nephrology2024

Effects of early recovery of renal function on adverse renal outcomes and mortality in patients with acute kidney injury: a systematic review and meta-analysis.

Yaling Bai, Yajing Li, JingJing Jin, Meijuan Cheng, Shenglei Zhang, Xinyue Yang, Jinsheng Xu

Registry-linked trialAbstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in International urology and nephrology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06570187 (The Effect of Dexmedetomidine on the Renal Functions in Septic Critically Ill Patients), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06570187 phase4recruitingnot on this map

The Effect of Dexmedetomidine on the Renal Functions in Septic Critically Ill Patients

TypeinterventionalSponsorCairo UniversityRan2024 to 2026Enrolled128ConditionsSepsis, Septic Shock, Acute Kidney InjuryArmsDexmedetomidine, Propofol
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yaling BaiDepartments of Nephrology, Hebei Key Laboratory of Vascular Calcifcation in Kidney Disease, Hebei Clinical Research Center for Chronic Kidney Disease, The Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Shijiazhuang, 050000, People's Republic of China.
Yajing LiDepartments of Nephrology, Hebei Key Laboratory of Vascular Calcifcation in Kidney Disease, Hebei Clinical Research Center for Chronic Kidney Disease, The Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Shijiazhuang, 050000, People's Republic of China.
JingJing JinDepartments of Nephrology, Hebei Key Laboratory of Vascular Calcifcation in Kidney Disease, Hebei Clinical Research Center for Chronic Kidney Disease, The Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Shijiazhuang, 050000, People's Republic of China.
Meijuan ChengDepartments of Nephrology, Hebei Key Laboratory of Vascular Calcifcation in Kidney Disease, Hebei Clinical Research Center for Chronic Kidney Disease, The Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Shijiazhuang, 050000, People's Republic of China.
Shenglei ZhangDepartments of Nephrology, Hebei Key Laboratory of Vascular Calcifcation in Kidney Disease, Hebei Clinical Research Center for Chronic Kidney Disease, The Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Shijiazhuang, 050000, People's Republic of China.
Xinyue YangDepartments of Nephrology, Hebei Key Laboratory of Vascular Calcifcation in Kidney Disease, Hebei Clinical Research Center for Chronic Kidney Disease, The Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Shijiazhuang, 050000, People's Republic of China.
Jinsheng XuDepartments of Nephrology, Hebei Key Laboratory of Vascular Calcifcation in Kidney Disease, Hebei Clinical Research Center for Chronic Kidney Disease, The Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Shijiazhuang, 050000, People's Republic of China. xjs5766@126.com.ORCID http://orcid.org/0000-0001-7634-2232

Funding

Center for Depression Research and Clinical Care, University of Texas Southwestern Medical Center 20577701DHebei Provincial Department of Science and Technology GZ2020013Natural Science Foundation for Young Scientists of Shanxi Province H2023206385the Hebei Provincial Excellent Talents in Clinical Medicine Training Project (2019)139the Hebei Provincial Specialty Capacity Building and Specialty Leader Training Project (2018)674the project of the Hebei Provincial Excellent Health Talents and High-Quality Development of Public Hospitals (2022)180
6 · The paper itself

Abstract

aimThis study intended to scrutinize the effect of RFR time on adverse renal outcomes and mortality and try to define the cutoff of early RFR.

methodsWe conducted a literature search from database inception to February 2023. Outcome measures incorporated the progression of CKD, delivery of RRT, incidence of composite renal outcomes, and mortality. And pooled results were depicted as odds ratio (OR) and 95% confidence interval (CI).

resultsA total of 11 studies were finally selected (507,989 patients, mean follow-up, 3.89 years). The results exhibited that the crude mortality was lower in patients with early RFR (OR = 0.39, 95% CI: 0.16-0.95, P = 0.037). In addition, patients with early RFR had a lower incidence of progression to CKD (OR = 0.38, 95% CI: 0.17-0.85, P < 0.018), RRT (OR = 0.37, 95% CI: 0.20-0.71, P = 0.03), and composite renal outcomes (OR = 0.18, 95% CI: 0.15-0.20, P < 0.001). CKD progression-related events were significantly higher in patients whose renal function recovered after 7 days (OR = 0.69, 95% CI: 0.47-1.09, P = 0.112) than in those whose renal function recovered within 7 days (OR = 0.23, 95% CI: 0.06-0.92, P = 0.038), and the risk of RRT was lower in patients who recovered within 7 days (OR = 0.32, 95% CI: 0.15-0.66, P = 0.002) than in those who recovered after 7 days (OR = 0.72, 95% CI: 0.17-3.09, P = 0.654) or longer.

conclusionPatients with early RFR had a lower risk of CKD progression, RRT, and composite renal outcomes, as well as lower crude mortality than those without early recovery, despite no marked difference in 30-day, 90-day, and 1-year mortality. We speculated that 7 days may be used as a cutoff for early RFR.

Indexed as

Acute Kidney InjuryRecovery of FunctionDisease ProgressionHumansKidneyTime FactorsAcute kidney injuryEarly recovery of renal functionLong-term outcomeMeta-analysisSystematic review

Identifiers

PMID38451431

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.